Cialis Side Effects

Cialis Side Effects

Male and female Cialis, like any other medicines, have their own contraindications and side effects. In this article, they are all described in detail. All risks and dangers are listed, too. Also, you can read about what can prevent the use of this medication and what cannot.

Cialis has a reputation as an effective medicine which is used for the treatment of erectile dysfunction, and its popularity continues to grow. This drug acts milder and longer than the well-known Viagra, but at the same time, it is much cheaper. Despite all these advantages, this drug, like any other medicine, has some side effects.

The effectiveness of Cialis is confirmed by numerous positive reviews from men who have already used this drug.

What Is Cialis?

Cialis is an effective drug which is based on tadalafil. Its main action is in the inhibition of the PDE5 enzyme, reducing the tone of penis smooth muscles and increasing blood circulation. The drug provides a stable, strong erection and prolonged excitement. The erection disappears naturally, with relief after ejaculation. The action of the drug starts only in presence of excitation (even minimal), otherwise there will be no effect.

How long lasts the medicine effect? Cialis starts its work at least 15 minutes after intake and lasts up to 36 hours. Cialis is not a hormonal treatment, so it doesn’t affect the level of testosterone and luteinizing hormones in the body of a man, and its effect on the internal organs is minimal. There is no effect on the quality of spermatozoa, so this medicine cannot prevent conception. If the couple has problems with conception because of the inability to have sex, then in this case, Cialis will contribute to pregnancy.

Cialis doesn’t affect the reproductive health of men, so it can be safely taken by men with BPH and prostatitis.

The drug is completely eliminated from the body within 36 hours by the kidneys and intestines. Its half-life is about 17.5 hours. The peak of tadalafil concentration in blood plasma comes 2 hours after intake of the pill.
Cialis Side Effects

How to Use Cialis Carefully?

The drug should be taken orally, with a small amount of tea or water. In some cases, the tablet can be divided into two parts (in order to reduce dosage), but this is undesirable. Pills are covered with a special coating and begin to dissolve only in the stomach. Man can use the one pill per day at any time, regardless of food intake. But, thanks to the long duration of Cialis, its daily intake is not recommended.

Erectile dysfunctionIt is better to start taking this drug at the minimal dosage of 2,5 mg or 5 mg. This dosage allows the identification of individual intolerance and possible side effects. If the effect of Cialis is insufficient and the drug is well-tolerated, the dosage can be increased up to 10 mg or 20 mg. Usually, 20 mg is sufficient to deal with severe potency problems, but sometimes the larger doses in 40 mg, 50 mg, and even 80 mg are acceptable.

It is important to pay attention to medications with a dosage of 80 mg and 100 mg. This dosage refers to the weight of the tablet itself, but not to the amount of the active component. In most cases, the mass of tadalafil in the tablet doesn’t exceed 20 mg, and the rest are auxiliary substances that allow prolonging of sexual intercourse. In any case, it is important to consult with a doctor before purchasing drugs with increased dosage.

Remember – the simultaneous intake of several tablets with a dosage of 20 mg poses a great danger for a man’s life!

The higher the dosage of the active substance, the greater likelihood of side effects’ occurrence. Therefore, it is important for men who use Cialis 20 mg to listen to their feelings. If unwanted symptoms occur, stop taking the medication immediately. Studies show that if 20 mg of tadalafil isn’t enough for successful fighting of erectile dysfunction, then the cause of impotency is not connected with vascular problems. This means that the man should to consult an andrologist and choose another treatment.

Cialis is a completely safe drug if to used properly – no more than once a day and at the prescribed dosage.

Also, it is important to know about the cases when Cialis is contraindicated to intake. They include:

  • age under 18 years;
  • serious diseases of the cardiovascular system;
  • stroke or heart attack, in the last 6 months;
  • constant intake of medicines that contain nitrates;
  • low blood pressure;
  • contraindication to physical exertion, incl. sex;
  • cases of priapism.

Common Side Effects

HeadacheSo, what are the common side effects? There are side effects of Cialis which are associated with improper dosage and uncontrolled drug intake. But sometimes side effects appear even during the proper use of medication. The common side effects include:

  1. Headache. The pain can be strong or weak, and passes after termination of Cialis action. You can take analgesics for mild pain, as a rule, they help. If the pain is severe, then stop taking the medication.
  2. Leg pain and back pain. Muscle aches and back pain are usually weak enough and don’t require analgesics. Such side effects are quite rare. Very rarely there are leg cramps and joint pain. It is important to make sure that the lower back pain is not caused by other diseases.
  3. Gastric disturbances. There may be indigestion, bloating, dyspepsia, constipation, diarrhea and weak pain in the stomach.
  4. Short-term vision impairment. Visual impairment is associated with changes in blood pressure and blood circulation in the eye, so when you stop taking the Cialis, vision will be quickly restored.
  5. Flushing due to increased blood circulation.

Rare Cialis Side Effects

One of the rarest Cialis side effects is an allergic reaction on the main active component – tadalafil. Usually it is a skin rash, including itching and redness. These reactions will go away soon after the excretion of tadalafil from the body. In rare cases, you will need to take antihistamines. Occasionally, an edema of limbs and eyelids can happen. Also, the development of conjunctivitis can be observed, too.

In some cases, mild dizziness and nausea may occur, and even more rarely there can be an increased nervous excitability and anger, as well as fluid retention in the body.

The most rare, but very dangerous, side effect of Cialis is priapism. In this case, the man has a constant painful erection which lasts more than 4 hours. Blood fills the penis and doesn’t circulate in it, and as a result of this, necrosis may begin. If this situation happens, it is necessary to immediately call a doctor and ambulance. Priapism occurs most often due to overdose of the drug, but it is can also be an individual reaction to tadalafil.

The claims that the remedies for improving potency cause melanoma or another type of cancer are not confirmed. Hair loss, weight gain, hemorrhoids, mood swings, ringing in ears, and stuffy nose are not related to use of Cialis. Memory loss and insomnia are not connected with this generic drug, either. Cialis use doesn’t cause depression state. All these troubles often occur in elderly men, because they most often use the drugs for ED treatment. If all these signs are found in young men, then they need to undergo a complex inspection of organs and systems of body.

Side Effects Depending on Cialis Type

Cialis 20mgThe occurrence of side effects largely depends on the dosage of the drug. The high concentration of tadalafil makes for a higher likelihood that the body will have a negative reaction to it. For this reason, side effects are mainly observed in men who take 20 mg or more, but are rare for those who use 2.5-5 mg tablets.

It is also very important to be guided by the state of your own health. Men with kidney failure need to take Cialis with a minimal dosage, because this will reduce the risks of various side effects. In addition, due to insufficient filtration of the liquid by kidneys, the effect of the drug is greatly enhanced, so a dosage of 5 mg is usually sufficient. The same applies to men older than 60 years of age, because their body reacts more strongly on tadalafil.

What if I Take Cialis And …

Cialis fits well with most drugs, as it doesn’t react with them chemically. The exception is only a few drugs. It is strictly prohibited to combine Cialis with narcotics.

Alcohol Drinks

Alcohol doesn’t react with Cialis and does not reduce its effect. A small amount of alcohol can even be useful (from a psychological point of view), since it helps to relax and not think about the difficulties with potency. But this applies only to a small amount of alcohol (a glass of wine or a bottle of beer). Large doses of ethyl alcohol negatively affect sensitivity, nervous conduction, and potency in general. A large dose of alcohol will worsen the quality of sexual intercourse, regardless of whether Cialis is used or not.

In rare occasions, some men reported mild dizziness after taking the generic together with alcohol. Also, alcohol in combination with a medicine can cause sleep disturbances and anxiety.

Food

Cialis doesn’t react chemically with food and drinks, but the exception is grapefruit juice. It contains substances that completely neutralize the effect of tadalafil. Also, this concern is also present with the juice of other citrus fruits. It is important to remember that when taking Cialis along with the fatty food, you must wait longer for the action to start. The effect will be noticeable only after 40-90 minutes after oral intake of the drug.

Other Medications

Interaction with alcohol, tablets, and grapefruitIf a man takes any medications, then before taking Cialis he needs to consult with a doctor and carefully listen to all of his warnings. Most drugs have normal reaction on the generic, but not all of them. Below is a list of drugs together with which you shouldn’t use Cialis.

  1. Some antibiotics. About this, it is necessary to consult with a doctor.
  2. Inhibitors that are prescribed for HIV and AIDS therapy.
  3. Some antifungal drugs.
  4. Medicines which contain nitrates.
  5. Drugs for hypertension that lowering blood pressure. With constantly lowered arterial pressure, Cialis intake is contraindicated.

Are Female Cialis Side Effects the Same?

What is female Cialis? This drug is not as well-known as the male variant, but it is also quite popular. It strengthens the sexual desire of woman, makes it more stable, and also provides a rush of blood to the genitals. Female Cialis is very effective when used by older women after menopause, as it increases excitement and reduces the dryness of vagina. Similar to the male Cialis, this drug works only if there is at least a little excitement. It can be taken once a day, but the duration of such medication should be limited. Long term use of the drug may lead to the occurrence of side effects. The use of female Cialis poses no danger in the form of side effects for partner.

Side effects of female Cialis are the same as for male. There can be headache, increased heart rate, and fatigue. When treating with generics, women don’t need to worry about their appearance, as the drug is not hormonal, doesn’t cause acne, excess weight, hives, hairiness, etc. Hearing loss, heartburn, cough, and blurred vision are also not connected with Cialis use. Before taking, it is important to carefully read the instructions, in which the all dangerous and negative effects are described in detail.

Female Cialis cannot be taken during pregnancy and lactation, and also cannot be combined with alcohol. The taking of medication during menses is contraindicated, too. Because of increased blood circulation, the drug cannot be taken if there are neoplasms, cysts or precancerous conditions present. Woman should discuss all possible risks and dangers of taking Cialis with her gynecologist.

Are Cialis Side Effects Different from Viagra’s?

Viagra pillsIf comparing Cialis vs Viagra, then these drugs are almost similar. The main benefits of Cialis are in the milder action which lasts for a longer time. Instead of this, the Viagra is stronger. Despite the fact that they contain different active components (for Viagra it is sildenafil), they increase blood circulation and have the same side effects.

Cialis vs Levitra Side Effects

If to compare Levitra and Cialis, it can be said that they are just similar drugs. The main active component of Levitra is vardenafil, which has effect identical to tadalafil and sildenafil. The side effects of all these substances are the same, too. The difference is only in the possible individual reaction (allergy) on the main active component.

What ED Pills Have Less Side Effects?

The strength of the side effects during proper medication depends on the individual characteristics of organism and dosage of the drug. Since Cialis has the mildest action, which is stretched in time, its side effects are much weaker. At the same time, if there is an allergy or other symptoms of intolerance, it will take longer for them to pass, in comparison to Viagra and Levitra, because Cialis is excreted in 36 hours.

Whichever drug will be chosen by the man, it is important to follow the daily dose, avoid the overdose and excessive mental strain during the period of drug taking, and also to adhere to the all precautions.

Purchase Cialis OTC at CialisBit Online Pharmacy

Purchasing in online shopCialis OTC should be bought only in trustworthy pharmacies, in order to not acquire the Chinese low-quality counterfeit or expired drug. Our CialisBit online store offers its buyers only high-quality goods at favorable prices. With us, you can buy not only Cialis, but also other drugs for ED treatment, such as Viagra, Kamagra 100 mg, etc.

The buyer will receive his goods within 7 days in any city of the USA. If the order was made for a sum more than $150, then the delivery will be free.

Tadalafil Dosages, Forms, Uses, Side Effects and Reviews

Tadalafil Dosages, Forms, Uses, Side Effects and Reviews

Cialis, known under the brand name tadalafil, is an absolutely revolutionary drug that struggles sexual dysfunctions. It is awesomely popular among men all over the world. What is its uniqueness? What other diseases does it fight against? Let’s discover all its features and the very best this powerful drug can do.

Every tenth men at the mature age suffers from sexual disorders. In many countries, Cialis has come a long way before entering the global pharmaceutical market and outstripped the sales of the legendary Viagra.

The giant pharmaceutical companies struggle for the chance to produce its magic formula. It is not weird. There are drugs that can provide similar effect, but an absolute analogue (except generics) does not exist.

Cialis drew the serious attention of the medical society. It appears that the power of the drug is not limited to erectile problems only, as the new research showed unexpected health benefits. What is its secret; who and how it can really help?

What Is Tadalafil?

Tadalafil is the active chemical component of the brand drug Cialis (Adcirca). Tadalafil belongs to the phosphodiesterase type 5 inhibitors (PDE5) drug class.

The uses of tadalafil are the following:

  1. Treatment of erectile dysfunction (ED). In particular, it treats the incapacity to achieve and maintain erection, including total, inconsistent inability or a tendency to sustain only brief erections. It does not increase sexual desire, and it does not prevent pregnancy or sexually transmitted illnesses such as human immunodeficiency virus (HIV), Hepatitis B, syphilis, and gonorrhea.
  2. Expectant treatment of benign prostatic hyperplasia (BPH), noncancerous enlargement of the prostate gland. Tadalafil helps to enfeeble painful and frequent urination.
  3. For improving the physical abilities in patients suffering from pulmonary arterial hypertension (PAH), a serious blood pressure condition that affects the arteries in the lungs and heart causing shortness of breath and fatigue.

It is a prescription medicine for daily usage or taking on demand. It may be used not only for main purposes listed above.

Researchers from the Cedars-Sinai Medical Center in Los Angeles discovered that tadalafil (Cialis), as well as sildenafil (Viagra), may be used in patients who suffer from Duchenne muscular dystrophy (DMD). This is a widespread ruinous illness among young males that has no specific cure. The mentioned PDE5 inhibitors helped boys to perform handgrip exercises. According to the information of the senior author, Dr. Ronald Victor, both drugs provided similar effects, though the effects of Cialis lasted longer (24 hours) as compared to Viagra (1 hour).

Also, Cialis was thoroughly checked for its benefits in sport performance. The clinical tests showed that it significantly improves testosterone levels. This feature is used by sportsmen who need to reach maximum power output in a moment. Increasing the «stress» response to the body, tadalafil helps to reduce the time of pick power reaching. But the chemical does not impact the total effect of exercise performance.
Tadalafil Dosages, Forms, Uses, Side Effects and Reviews

Short History

Cialis is an outcome of cooperative work between Glaxo Wellcome and the biotechnology company ICOS in Washington which started in 1991. Initially ICOS worked at the IC351 (PDE5) inhibitor. Concurrently in 1994, Pfizer scientific researches ascertained new feature of their product sildenafil (Viagra in the future).

Although ICOS workers did not intend to tailor an ED drug, Pfizer claimed it caught their attention, and they started working towards that end. ICOS certified the chemical IC351 in 1994 and started research studies on it in 1995. The tests in 1997 showed significant effect of tadalafil on males with ED problems. After successful ending phase 3, Cialis was given approval by the Food and Drug Administration (FDA).

Firstly, the partnership of ICOS and Glaxo was based on half of the profits from Cialis distribution. Later, Glaxo disproved the contract due to a mismatch of Cialis to the key products of the market outlet.

The amalgamation of companies ICOS and Eli Lilly happened in 1998. The new-formed biological corporation Lilly ICOS continued developing and commercializing tadalafil as an ED drug. They applied to the FDA again in 2000 for approval IC351 under the generic name of tadalafil and brand name of Cialis.

In May of 2002, during scientific research the main feature of tadalafil which distinguishes it from similar PDE5 inhibitors was discovered (Viagra, Levitra): it effectiveness lasts up to 36 hours.

In 2007, Eli Lilly & Co acquired ICOS for US $2.3 billion and become a fully legitimate owner of Cialis.

Is Tadalafil Approved by FDA?

Erectile dysfunctionOn May 28, 2009, the FDA approved tadalafil for PAH therapy. It was the first once-daily PDE5 inhibitor for PAH medical maintenance.

On October 6, 2011, Cialis was endorsed for BPH treatment, becoming the first drug for this purpose. Scott Monroe, director of FDA’s Division of Reproductive and Urologic Products, stated that BPH and ED are often concomitant disorders, and Cialis becomes a convenient option. Daily usage was allowed by FDA as well for treating urinary symptoms in males who suffer from BPH.

Cialis was approved for the curing of erectile problems on November 21, 2003. It was the third prescription medicine for ED on the pharmaceutical market of the USA after Viagra (sildenafil) and Levitra (vardenafil).

Is tadalafil a controlled substance? Yes, of course. This drug is strongly protected by the FDA. In 2015, US officials confiscated a shipment of forgery Cialis versions. The batch was chemically analyzed. The incoming drugs included tadalafil and sildenafil together, which is absolutely inadmissible and rife with negative health consequences. «Cialis» was misspelled on one side of the bottle. The country of the manufacturer was Australia, where Eli Lilly has not been manufacturing human drugs for 30 years. Other signs specific for counterfeit production were found, too.

The FDA strongly prohibits the importation of prescription medicines from overseas. The incoming packages are held back by Customs and Border Protection in the United States. The suspected products undergo close examination. The FDA appeals for team play with clinicians and users and asks them to inform them about suspicious medical products anonymously. It highly cooperates with Interpol and other law machinery to find sellers of fake medications.

How Tadalafil Works

ErectionFor better understanding the drug effect, it is useful to know how tadalafil works. Cialis acts similarly to other PDE5 inhibitors. Its function consists of averting the quick action of the PDE5 ferment. It naturally acts in the phallus. The main feature which differs Cialis from other equal medications is its prolonged working time (up to 36 hours).

To achieve an erection, the phallus should be filled with blood. Massive blood circulation in the genital area enlarges it and provides rigidity. The male’s body in an aroused state releases nitric oxide in the phallus, proceeding cyclic guanosine monophosphate (cGMP), a ferment which is responsible for the regulation of blood vessels in size. While PDE5 destroys cGMP, causing a weak blood circulation and a flaccid phallus state respectively, Cialis helps to achieve and maintain erection, inhibiting the damaging activity of PDE5. Presence of cGMP is necessary for a stable and rock hard erection.

The mechanism of action for BPH is unclarified. Possibly the existence of a PDE5 inhibitor in the prostate gland and the bladder helps easy urination through reducing pressure on the muscles and regulation the urine flowing.

It is very important to know not only the effect of tadalafil but also how long does it last, as this is its main feature among other similar preparations. The elimination half-life of tadalafil is long — 17.5 hours. The longer the half-life period is, the longer the activity of the preparation is. That is why the drug has received the name the «weekend pill».

The prolonged period of action lends itself well to daily regimen. As far as it implies intake of lower doses, the steady-state plasma concentrations are attained within 5 days of daily intake. Even more, the index is greater when tadalafil is taken on a daily basis rather than intermittently.

Within 5 days of Cialis intake in dosages 2.5 mg and 5 mg, the plasma concentration indexes are 4 mg and 8 mg, respectively. Taking the drug daily was allowed by the FDA in January 2008 on the base of clinical conclusions. Daily dosing is also suggested to reduce the risk of possible side effects which are more likely to occur after intake of larger doses intermittently.

Tolerance to the therapeutic effect of tadalafil, which may cause the decreasing of drug effectiveness and possible failures in treatment course, does not happen during 6 months of treatment for males with ED.

Tadalafil is eliminated out of the body primarily as metabolites in excrement and urine.

Tadalafil Dosages

Cialis tabletsCialis tablets come in dosages 2.5 mg, 5 mg, 10 mg, 20 mg, 40 mg, 60 mg, 80 mg, and 100 mg, 200 mg.

The suggested dose for different regimens:

  1. On demand schedule. 10 mg of tadalafil should be taken half an hour before sexual intercourse. The dose may be corrected depending on the user’s response: decreased to 5 mg or 2.5 mg in case of good effectiveness but unwanted side effects manifestations, or increased in case of well acceptance but weak effect.
  2. Daily schedule. 2.5 mg once a day, preferably at the same time, regardless of sexual intercourse. It may be increased up to 5 mg depending on the patient’s individual response.

For treatment of BPH symptoms, 5 mg of tadalafil should be taken once a day at the same time. It is important to remember that tadalafil is an additional symptomatic treatment which should be applied along with other specific medications for a BPH cure. The same dosage is suggested if BPH and ED diseases are concomitant.

As practice shows, the classic and most frequently prescribed dose of Cialis is 20 mg. Both drugs, 20 mg and 100 mg, provide the same result. High dosage does not mean 5 times higher efficiency, it is just another way of consumption.

According to clinical trials, Cialis 100 mg showed gradual results as compared to 20 mg. A high concentration of the active ingredient is useful for those who want to change basic drugs from short time pill’s action for a longer time.

Since the first ED pills appeared on the counters as 100 mg, other manufacturers keep on the same line. During consumption of one active ingredient, the user’s body is acquiring a kind of habit to it which should be replaced when another substance comes. To avoid negative health changes, it’s suggested to wait shortly before the previous ingredient goes out of the organism.

Forms of Drug

Cialis is manufactured in multiple medical forms for maximal convenience for the consumer. Other than the habitual rigid form, drugs provide the same efficiency as classic tabs as long as they contain the same active ingredient tadalafil.

The main difference between them all is the method of consumption and the start of the working period. Some forms promote better assimilation and digestion due to quick absorption, quickening the onset of action to start eventually. Choosing a different form, consumers should pay attention to the measure of the active ingredient.

The known forms of Cialis introduced into the pharmacy market are below:

  1. Rigid tablets. The classic film-coated form which should be used without damaging, splitting, or chewing along with a glass of water.
  2. Liquid. Tasteless and clear syrup with no delays in action. The clinical trials showed minor or mild side effects, such as runny nose, mild sore head, and vertigo with diminishing risks for health. The appropriate dose of citrate liquid is 5 ml.
  3. Soft tabs (e20, sublingual). A new, upgraded, and better chewable form of Cialis with a pleasant taste which drives a user more to have sex. Its main benefit is its absorption directly into the bloodstream and faster action consequently. The pills should be chewed or dissolved under the tongue. The medicine can be consumed right after a square dinner regardless of the meals calorific value.
  4. Soft gel capsules. One of the quickest ways to achieve results. Quick solubility provides faster results: the medication starts acting within 10-15 minutes after consumption. It is suggested for senior males who find it difficult to gulp standard pills.
  5. Oral jelly. It is a convenient form for those who have difficulties swallowing rigid pills. The content of the sachet should be placed right into the mouth. Once the remedy is dissolved, wash it down with water. The preparation is available in a various range of flavors.

Thusly, thanks to resourceful generic manufacturers, users do not have problems with tadalafil consumption. Among various forms, every man will find the best medicine for himself.

Tadalafil Brands

Production of tadalafilCialis patent expiration extends at the earliest on September 27, 2018. According to a reached settlement with generic producers, the patent is set to expire in 2020. The branded product is available only in 20 mg classic rigid form.

Being one of the most popular medicines, Cialis is widely available at the pharmaceutical market under other brand names. It would not be too much trouble for users to find another form and dosage.

Generic Cialis has no significant differences from the brand mark because the manufacturers comply with the demand and apply already invented composition. It means that generic interpretations offer the same efficiency and high quality. Auxiliary chemicals can be replaced, but that does not impact its medical activity.

Unlike original Cialis, which is produced in the USA, generic products are mainly manufactured in India and third-world countries. The costs for generics are in many times lower, because the compositions are ready. It does not require a lot of time, investments, and other necessary-for-approval procedures. Marketing issues do not require major expense either, because the product is already known. These notable factors define generics’ cheap prices. Eventually, users have a great chance to save and get the needed drug at affordable prices.

A few examples of generic names:

  • Tadalis (Ajanta Pharma Ltd.);
  • Tadalista Super Active (Fortune Health Care);
  • Vidalista (Centurion Laboratories);
  • Tadora (German Remedies Pvt. Ltd.);
  • Tadacip (Cipla Ltd.);
  • Apcalis (Ajanta Pharma Ltd.);
  • Super Tadarise (Sunrise Remedies Pvt. Ltd.);
  • Forzest (Ranbaxy Laboratories Ltd.);
  • Cialis Professional (Sunrise/Aurochem/Dharam).

Tadalafil is also used as a compound in combination with other chemical agents. Tadapox is a generic version of Cialis which is used in combination with dapoxetine. The renovation formula treats not only ED problems but also premature ejaculation (PE).

Sildalis is a combination of tadalafil and sildenafil (the compound of Viagra). It is double effectiveness for the treatment of sexual problems in males which works up to 48 hours.

All tadalafil variations are the Rx medicines and require a preliminary medical consultation.

Difference Between Cialis and Tadalafil

After the brand Cialis entered the pharmaceutical market, many users estimated its excellent and prolonged effect. Giant pharmaceutical companies were eager to earn on this drug, too. The producer holds the exclusive rights for Cialis, but the patent was helpful. When the patents are near the expiration date, other producers requested permission to manufacture the same pill under their own trademarks and add it specific features if they wish. In this way, omnifarious jellies, capsules, and other types of tadalafil appeared in the global pharmacy market.

Original and generic versions both are manufactured according to standards of quality. Generics also have to receive the law endorsement and pass through numerous relevant procedures. Only this order guarantees equal effectiveness to the brand production. All the main chemical qualities remain the same.

So, what is the difference between Cialis and tadalafil?

  1. Price. Tadalafil costs half as much as original Cialis. Producing a copy of original product, the best way for the manufacturers to attract consumers is setting a low cost. Besides, the manufacturing process does not cost much for them, as was mentioned above.
  2. Multiformity. A successful marketing hook which provides more convenience to the users. Containing the same active substance, jellies, capsules, and other medicines meet the needs of the most demanding customer. The original Cialis is available only in the form of classic rigid tabs.

Thusly, users can be sure and calm: buying tadalafil instead of brand Cialis, they will receive the desired effect.

Who Can Use Tadalafil?

Cases of tadalafil usesTadalafil is a prescription drug which is intended for males, although in some cases it can be used in women and cautiously in children. Cialis is certified for the treatment of ED treatment and PAH therapy, but it may be adapted to cure particular rare diseases, too, if a healthcare provider finds tadalafil usage appropriate. Let’s examine, what tadalafil is used for:

  1. ED treatment. Tadalafil cannot be used by sexually active people who are under the age of 18. It has been widely tested and proved for male usage. Tadalafil can be used by females, too, for solving sexual arousal problems. Cialis for women exists in the pharmaceutical market, although the clinical studies on this matter are limited.
  2. PAH therapy. Tadalafil can be used by males and females with PAH. No difference in negative health reactions have been reported. Tadalafil was tolerated well in children with PAH and showed more efficient and safer results than sildenafil in the same purpose.
  3. Symptomatic treatment of BPH in males. Improving bloodflow to the genital area, tadalafil helps to relax muscles of the prostate and bladder, reducing symptoms of trouble with urination.
  4. Raynaud’s phenomenon (deficient blood circulation to the hand and fingers caused by freeze burn or heavy stress). Tadalafil reduces the duration and frequency of secondary episodes in male and female patients with scleroderma and mixed connective-tissue disease.
  5. Duchenne muscular dystrophy (muscle degenerative disease, mostly diagnosed in boys between 2-7 y.o.). Tadalafil increases lipid metabolism and protein synthesis efficiency, as well as promotes a better action network management at Z-disk.

The efficiency of PDE5 inhibitors in clinical cases, among ED problems, has been under the scrutiny of medics. Possibly a list of ailments that are treated by tadalafil will be added shortly.

Is It Used for Pulmonary Hypertension?

Tadalafil is officially approved for the treatment of PAH. The progressive illness is defined by the chronicle rising of the pulmonary arterial pressure that often leads to failure of the right side of the heart and early death. The mechanisms of disease development is poorly understood and no specific cure is known today, except approved treatment options including PDE5 inhibitors.

PAH is connected with the impaired release of nitric oxide at least partially because of the reduced expression of its synthase in the vascular endothelial tissues of pulmonary arteries. Tadalafil makes a relaxing and dilating action on the muscle cells in the walls of blood vessels to lungs, reducing the pressure in blood pathways and making blood circulation easier. Good blood circulation improves physical health and the ability to exercise.

Long-term treatment with tadalafil was well-tolerated. Tadalafil in doses 10 mg, 20 mg, and 40 mg (but not 2.5 mg) significantly improved the walked distance at the 16th week. Tadalafil 40 mg showed the best statistical significance. After all mentioned doses, mild or moderate adverse events were displayed. The dose 40 mg significantly decreased the incidences of clinical worsening.

The studying has demonstrated the safety and effectiveness of tadalafil for the treatment of patients with symptomatic PAH. The 40 mg dose offers clinically meaningful additions to the main approved treatment.

Safety

Those who are interested in Cialis but concerned whether is it safe should be sure: Cialis is a safe drug. Multiple clinical trials have proven that tadalafil can be used on an on-demand or daily basis with no harm to health. Taking it daily is more efficient and reduces side effects manifestations.

However, it is very important to take it according to rules stated by the FDA. Cialis must be used only after a preliminary medical consultation. The clinician should inform a patient what is Cialis, how much drug will provide the best effect, when to take the drug, and how to use it.

SexCialis should be excluded if a patient:

  • is prohibited to have sex due to weak state of cardiovascular system;
  • suffers from heart illnesses (chest pain, irregular heartbeat, heart failure);
  • has had a heart seizure recently (in the last 90 days);
  • has sustained a stroke (in the last half of year);
  • experiences blood pressure drops;
  • has one eye vision due to non-arteritic interior ischaemic optic neuropathy;
  • practices recreational use, especially amyl nitrite, butyl nitrite that were breathed in;
  • has allergy to ingredients of the drug.

During a medical examination, a patient should necessarily inform healthcare if these impairments take place:

  • chronic liver or kidney illnesses;
  • heart and blood vessels ailments;
  • sickle cell disease;
  • cancer formed by malignant plasma cells (multiple myeloma);
  • cancer of the blood (leukemia);
  • phallus deformation (penile fibromatosis);
  • blindness.

The drug and its correct doses must be prescribed individually according to their state of health. Never share the drug with anyone, even if the symptoms look similar.

Cialis shelf life is 2 years from the date of producing. Never use an expired product and instead discard it.

How and When to Take Tadalafil Pills?

It is highly suggested to stick to the rules that are created for a safe treatment course. These simple steps will help to avoid negative reactions and have the maximum effect for a patient:

  1. Before taking tadalafil, read the annotation carefully. It provides information about the tabs and full list of possible side effects a patient might experience.
  2. Take the drugs strictly according to the scheme prescribed by a personal clinician.
  3. One dose should be taken only once a day. Do your best to take it at the same time of the day.
  4. The medicine should be taken along with a glass of water regardless of meal time.
  5. One forgotten dose should be taken as soon as a patient remembers. Two or more forgotten ones should be left out. A patient must continue following the ordinary regime further. Never use a double dose to compensate the missed tab, as it will cause an overdosing effect.
  6. Regular appointments with a private healthcare provider will help to monitor the progress or correct the treatment scheme if needed.
  7. Before a surgery, inform a medical specialist about using tadalafil.
  8. Before starting the next pack of the drug, make sure that it is the same as the previous one.
  9. Be cautious about using tadalafil together with other medicines. Consult with a doctor regarding every particular over the counter (OTC) and Rx drug.
  10. After first consumption, avoid driving or operating machinery until you know how tadalafil affects your body.

Remembering and keeping to these easy rules will help to avoid many possible problems in future and reach progress shortly.

Overdose

Tadalafil overdose symptomsTaking too much of the drug may cause numerous unwanted reactions; that is why following the treatment scheme is very important. In case of sudden overdose a patient should contact a personal clinician or contact a local medical center right away. There is no specific cure for overdose. A patient will be provided supportive care.

Tadalafil overdose symptoms include:

  • chest pain;
  • abnormal heart rhythm;
  • vertigo;
  • lightheadedness or fainting;
  • queasiness.

Overdosing may rise up the risk of adverse events, for example:

  • sore head;
  • stomach upsets;
  • blushing;
  • backache, muscle aches;
  • upper and lower extremities pain;
  • stuffy nose.

It is always better to prevent overdose. Remembering the simple rules of usage will help to exclude these problems:

  1. The active ingredient stays in the body up to 72 hours. The patients on an on-demand base of treatment are suggested to mark the days when they consume tadalafil in the calendar.
  2. Do not increase the dose independently if the prescribed dosage showed a weak effect. Highly likely, a patient abused the rules of taking the prescribed once and, as a result, has not received the desired effect again.
  3. Do not mix tadalafil with drugs that highly interact with it.

New patients might be worried in the beginning of the course, but soon they will get used to the regime and just enjoy the drug’s effect.

Side Effects of Tadalafil

Cialis was taken by over 9000 men in the world. Its clinical trials for daily regime lasted 6 months, 1 year, and 2 years. The studies for use on an on-demand basis lasted 6 months and 1 year.

Diagram 1 represents the frequency of reported side effect manifestations in patients with regular daily treatment for 12 weeks. The middle age of patients was 58 y.o.(from 21 to 82).

Cialis side effects diagramDiagram 2 shows the frequency of reported adverse events in patients who used Cialis on demand. The data was taken for the same period of 12 weeks. The middle age was 59 y.o. (from 22 to 88).

Cialis adverse effects frequency diagramThe test results were estimated after tadalafil had been approved. The monitoring was done through volunteering from an unlimited number of people. Therefore, it is barely conceivable to provide more accurate statistics of the side effects frequency. The symptoms based upon the above studies have been marked due to their seriousness, regularity of reports, deficiency of other manifestation reasons, or all these factors together.

The character of side effects is individual. Many people do not experience any negative health changes at all. Remember that Cialis is prescribed by a healthcare provider only when the advantages outweigh disadvantages.

Patients are suggested to appeal for medical advice in case of any unusual reactions or rapid negative health changes immediately. It is not always necessary to reject the drug completely. A clinician may suggest a few useful tips that help to overcome side effects easily or correct the dose of intake.

Common

The vast majority of side effects after tadalafil consumption do not require medical assistance and go away by themselves as soon as a patient’s body gets used to the new preparation.

Nevertheless, if the character of symptoms is annoying and prevents the person from remaining in the normal living environment, a patient should appeal for medical consultation. The specialist will suggest simple methods or remedies which should help to overcome the symptoms. Long-term side effects are a sign for monitoring the drug’s effect and practicability of its further usage.

The most frequently reported reactions are represented in the table.

More CommonLess CommonRare
DyspepsiaNose bleedingColor vision defects
Overall body ache
Crawling
Itch
Numbness
Dry, burning or itching feeling in the eye
Chest burning
BurpingStuffy nose
Motion difficulty
Swallowing difficulty
Thirst
Throat inflammation
Swollen lymph nodes
Pain in the eyes
Excess fluid in the eye
Acid refluxConstant sensation of motion
Blushing
Warmth and redness of arms and upper chest
Ague
Husk
Voice mutation
Erection enhancement
Weakness
Stomach upsetsDiarrhea
Muscles aches or spasms
Muscle rigidity
Neck, arm, leg pain
Hypoesthesia (sensitivity loss)
Rheum
Dizziness
Somnolence
Abdominal painPoor sleep
Insomnia
Sudden erection
Indigestion
Puffy eyes, face
Joint effusion
Blear-eyedness
Abdominal tenderness

Remember that side effects do not necessarily appear in every single case. Many users do not feel any health changes at all and successfully continue the treatment course.

More Serious

Serious side effects are not widespread but possible. If a patient experiences acute symptoms, it is necessary to examine them at a medical center. The table below represent the states which demand medical attention.

Less CommonRareIsolated incidents
Jaw, arm pain, backachePriapism (painful erection for hours)Abdominal ache
Foggy visionBlindness
Chest pain troublesSkin blisters, peeling, abrasion
Heavy or tight feeling in the chestCracked skin
Scaly skin
DitherCough
Cold sweatsVision decreasing or defects
Mental fogLoose stools
FatigueTrouble speaking, slow speech, muteness
SyncopeDiplopia (double vision)
Vertigo from standing upArrhythmia
Abnormal heart rhythmsMigraine
Sore headRash, wheals
DeafnessNumbness of facial muscles or extremities
NervosityMyalgia
Pulse beat in the earTingling in extremities
Short breathInflamed eyes
Feeling exhaustedCutaneous lesions purple in the middle
EmesisSkin redness and swelling
Ulcers, white spots on the lips or in the mouth
SicknessLower extremities swelling
Sudden cardiac arrest

Sudden blindness is obviously one of the most scarring symptoms for patients. It happens in a very small number of people as a result of decreased blood circulation to the optic nerve. The most vulnerable are individuals over the age 50 with:

  • hypertension;
  • high cholesterol levels;
  • heart ailments;
  • diabetes;
  • eye problems.

It is unsure if tadalafil initiates sudden blindness in the cases listed above. Nevertheless, if a patient feels any vision defects during the course of Cialis, he should appeal for medical help immediately.

Interactions

Blood pressureRegardless of consumption schedule, two or more medicines may interact with one another. This process increases or decreases the efficiency of the medicines or causes unwanted reactions. Patients who use more than one medicine during the same period should be cautious.

The interwork appears between drug substances or a mixture of medicine with food. The interaction leads to changes in absorption, metabolizing, or elimination. Quite often it happens when two drugs have a similar assignment or provide canceling reactions. As a result, a patient may not receive the desired effect from the preparations or his health condition may drastically worsen.

When two drugs enhance a benefit without side effects, they can be parts of one treatment course. For instance, drugs that lower blood pressure through different working mechanisms may be used together because they enhance the effect and work better than one particular drug alone.

Drug leaflets always contain information about potential drug interwork. The mentioned reactions are chiefly unpredictable and occur individually in every person. The factors which impact on drug interactions are:

  • genetic predisposition;
  • physiological characteristics;
  • age;
  • life mode (diet, sport);
  • primary diseases;
  • drug dosages;
  • continuance of combined cure;
  • schedule of intake (some interactions may be excluded by taking the medicines at different time of a day).

Here are a few tips how to avoid drug interactions during Cialis treatment:

  1. Inform a clinician about the complete list of Rx and OTC drugs you have been using regularly or seldom, including herbal supplements, vitamins and nutraceuticals.
  2. Impart the period when preparations were added or rejected.
  3. Let a healthcare provider know about your lifestyle, sport involvement, special dietary regime or alcohol dependency.
  4. Receive the complete information about Cialis interactions, in particular the most frequent and serious ones.
  5. Discuss with a personal physician the elimination of unnecessary preparations or switching the most potential for interaction drugs.

The drug interaction provides only general data based on clinical research, but it can barely predict every possible situation. Derive maximum benefits from it by minimizing the risks of negative interworks and improving success of the cure.

Can I Take Tadalafil While Drinking Alcohol?

Alcohol drinksExcessive alcohol consumption may cause serious adverse events. This fact is explained by the similar action of spirituous beverages and the chemical substances: they are vasodilators, which means they widen blood vessels and reduce blood pressure.

Orthostatic hypotension is the most frequent result of Cialis and alcohol combination.

The signs of orthostatic hypotension are:

  • headache;
  • fast heart rate;
  • vertigo;
  • swoon;
  • different physical traumas caused by the states listed above.

Alcohol in small amounts does not cause any serious problems and can be used with tadalafil. Moderate drinking (less that three spirituous beverages per day) is allowed. Tolerated doses per day are represented in the table.

DrinkAllowed dose (oz)
Beer12
Wine5
80-proof liquor (vodka, gin, rum, whiskey, tequila)1.5

Those who drink alcohol regularly and consume more than 3 drinks daily should visit a counseling psychologist. Cialis is not suggested to people who suffer from chronic alcoholism due to increased risks of heart ailments, adiposity, and brain diseases.

Give your healthcare provider truthful information about your alcohol habits during the first medical examination. It will help to avoid potentially dangerous pathologies.

With Food

GrapefruitUnlike other ED drugs, tadalafil shows good effectiveness regardless of the types of food and time of meal, though users have marked that its effect is still better when tadalafil was taken on an empty stomach or after food.

The warning about grapefruit juice remains unchanged for all drugs and tadalafil is not an exception. Being a good source of vitamin C, grapefruit reduces the pharmacologic effect of the drug, causes the accumulation of the chemical substance in the organism, and provokes multiple side effects, such as:

  • vertigo;
  • lassitude;
  • sore head;
  • sickness;
  • indigestion.

By and large, preventing the breakdown of tadalafil, grapefruit and grapefruit juice actually causes overdosing which is extremely dangerous.

Patients who use Cialis on a demand basis should be especially cautious. The components of this product stay in the stomach up to 72 hours. Remember that after consuming at least one glass of grapefruit juice, you should wait at least 3 days before taking Cialis. The best way out is to exclude this product you’re your diet during a Cialis treatment course.

What Other Drugs Will Affect Tadalafil?

There are a few groups of drugs which Cialis highly interacts with. The medications that are not suggested for parallel intake with Cialis or the ones which require an individual scheme of cure are represented in the table.

Drug classExamplesInteraction resultRecommendation
CYP3A4 Inhibitors.

Erythromycin (E-mycin);

Itraconazole (Sporanox);

Indinavir (Crixivan);

Isoniazid;

Ketoconazole (Nizoral);

Nefazodone (Serzone);

Nelfinavir (Viracept);

Nicardipine (Cardene);

Posaconazole (Noxafil);

Ritonavir (Norvir).

Decreasing the breakdown and elimination of tadalafil out of the organism.The doses must be adjusted.
Hypertension medicines.

Lisinopril (Qbrelis);

Atenolol (Tenormin);

Bystolic (Nebivolol);

Diovan (Valsartan);

Amlodipine (Norvasc);

Benicar (Olmesartan);

Losartan (Cozaar);

Carvedilol (Coreg);

Avapro (Irbesartan);

Tekturna (Aliskiren).

Tadalafil decreases blood pressure. Mixing preparation leads to hypotension.Combining is not suggested.
Alpha-adrenergic antagonists.

Alfuzosin (Uroxatral);

Doxazosin (Cardura);

Terazosin (Hytrin);

Tamsulosin (Flomax);

Prazosin (Minipress);

Phentolamine (Regitine);

Phenoxybenzamine (Dibenzyline);

Silodosin (Rapaflo).

Combining causes hypotension.Individual consultation is required.
Nitrate-containing medicines.

Isosorbide dinitrate (Isordil);

Nitroglycerin;

Isosorbide mononitrate (Imdur);

Amyl nitrite “poppers”.

Parallel intake causes life-threatening blood pressure drops.Never take these drugs together.
Other phosphodiesterase type 5 inhibitors

Sildenafil (Viagra);

Vardenafil (Levitra).

Priapism, multiple side effects.Do not use different ED drugs together.
Bronchodilator.Theophylline (Aerolate, Slo-bid, Theo-Dur).Concomitant use increases heart rate.The dose corrections are necessary.

The drug interaction list is represented for review and does not cover all drugs with which Cialis interacts. Contact a medical center to receive detailed information regarding every particular medicine.

Tadalafil Reviews and Ratings

Tadalafil has many fans all over the world. Men love Cialis because it is a really effective medicine. All chemical characteristics are correct and the «weekend pill» works in the claimed time.

Many users were happy to find an absolute absence of side effects, which helped them to enjoy the sexual performance. Only a few customers did not feel the effect in the beginning of the course starting from a low dosage.

Consumers whose insurance does not cover Cialis cost complain about the high price of the original product. Those who have been using generics feel no inconveniences with high prices. No prescription is also a reason why users chose generic interpretations.

According to the online reviews, Cialis has got 8.7 voices of 10, where 57% of users have given the highest rates to the medication.

Comparison

Premature ejaculationTo choose an alternative preparation, it is important to understand how tadalafil works, what is its effect, and how long does it last. In fact, Cialis is a single medicinal product which provides a guaranteed effect up to 36 hours. Its unique formula distinguishes it from other similar ED drugs which do not possess such long periods of action.

Due to Cialis side effects, users might seek a herbal substitute first. Natural ingredients are usually well-tolerated without adverse reactions, plus prescribing information is not needed. But can their power compare to the strength of a modern medical product?

Many famous remedies for ED treatment that are made from plants were clinically tested and really showed some effect in ED treatment. They support physical and mental energy and stamina. Unfortunately, most of them are unproven and associated with possible risks. The lack of safety information still requires preliminary medical consultation.

It should be noted that mechanism of action of the natural drugs is not instantaneous. The results of their efficacy are shown within a period of regular intake which sometimes takes up to 2 months. Therefore, it’s not the best option for those who need an immediate result in a matter of hours. Possibly, natural drugs could be good preventive measures for escaping ED and PE problems in the future, but medics can not guarantee the results in the curing of current impairments.

Despite positive promised effects and simple usage conditions, receiving the consultation of a homeopathist and a naturopath before starting the herbal treatment course is highly suggested.

Tadalafil Vs Sildenafil

Cialis and Viagra (sildenafil) are designed for ED treatment. Belonging to one drug class, they have significant differences. A patient should choose only one preparation according to chemical characteristics. Taking drugs with identical purpose may lead to abnormal erections and various side effects.

CriterionTadalafilSildenafil
Brand nameCialisViagra
Price for original product (10 tablets)*$339-$401 ($37 per pill)$218-$320 ($25 per pill)
Without prescriptionNoNo
GenericsTadalafilSildenafil citrate
Dosages2.5 mg, 5 mg, 10 mg, 20 mg, 40 mg, 60 mg20 mg, 25 mg, 50 mg, 75 mg, 100 mg, 150 mg, 200 mg
Working start after consumptionWithin 15-20 minutesWithin 30 minutes
DurationUp to 36 hours4-6 hours
IntakeRegardless of meal time. Grapefruit products are not allowed.Taking on empty stomach or after a light meal. No grapefruit products can be used during the treatment course.
Sales claim«Weekend pill» with action up to 36 hoursThe first ED drug, safe and successful
Adverse reactionsBoth drugs may cause mild, moderate or serious side effects

*Prices may vary depending on the seller

Both drugs are effective and widely used in ED treatment all over the world. Viagra was the first drug in the pharmaceutical market, Cialis appeared later and is considered to be a modern drug. Those who want to achieve a quick and long-lasting effect should doubtlessly choose tadalafil as a superior drug for ED.

Versus Vardenafil

Vardenafil is an active ingredient in the famous and effective ED drug, Levitra.

It belongs to the PDE5 inhibitors drug class which means it works similarly to Cialis and Viagra. But differences still exist. Let’s check them out in the table below.

CriterionTadalafilVardenafil
Brand nameCialisLevitra
AssignmentFor ED
Dosages2.5 mg, 5 mg, 10 mg, 20 mg, 40 mg, 60 mg
Price for generics (per pill)$0.79-0.99 per pill
Price for brand product (10 tablets)$339-$401 ($37 per pill)$341-$450 ($40 per pill)
EffectivenessWorks in 85% casesWorks in 92% cases
Sales claim«Weekend pill» with action up to 36 hoursHelps in cases when Viagra was ineffective
When to take15-20 minutes before sexual activity1 hour before sexual activity
Consumption recommendationsRegardless of meal time. No grapefruit products in ration.
DurationUp to 36 hours5-7 hours
Half life18 hours4-5 hours

As we can see, tadalafil does not have competitors in its duration of action, taking the stable leading positions among other PDE5 inhibitors, although Levitra should not be underestimated, as well. It was the third approved drug for ED treatment in the US, and it also possesses good therapeutic qualities.

Tadacip Vs Tadalafil

Tadacip is a name of generic Cialis with the active ingredient tadalafil manufactured by Indian company Cipla. It is a relatively new preparation which is available and identical to the brand drug. The distinguishing factors are examined in the table.

CriterionCialisTadacip
Active ingredientTadalafil
AssignmentFor ED
Activity period32-36 hours
Working start after consumptionWithin 15-20 minutesWithin 40 minutes
Dosages2.5 mg, 5 mg, 10 mg, 20 mg, 40 mg, 60 mg20 mg

In view of the fact that both drugs contain the same active ingredient, they have more similarities than differences. Its price varies from $1.10 to $3.59 per tablet, which is significantly less than the price of the brand Cialis. This factor appears to be the main advantage of Tadacip.

Buy Tadalafil at Online Pharmacy

Purchasing in online shopThose who are thinking about where to buy Cialis and how to save money should not seek further. Buying tadalafil in an online pharmacy is the best option for those who do not want to pay extra money for the expensive original product. Purchase it in our drugstore CialisBit and have many advantages.

We sell the Indian generics of pure quality and offer the most famous and highly effective drugs for ED and PE (Viagra, Priligy, and many more) at the cheapest prices without a prescription. Discount for Bitcoin payments (-35%) is a bonus for our customers. Quick shipping will not keep you waiting, as the packages are sent through all the US states within 7-18 days. Professional customer service members will gladly answer all your questions regarding the choice of the preparation, payment, or delivery issues.

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Sildenafil Dosages, Uses, Side Effects, Mechanism of Action

Sildenafil Dosages, Uses, Side Effects, Mechanism of Action

The appearance of sildenafil in the pharmaceutical market was a world breakthrough. Being the first remedy for the professional treatment of erectile dysfunction in males, it has saved many families and relations. What do users love sildenafil for? Is this legendary drug really magic? Let’s speak about sildenafil characteristics and its analogues.

Viagra is a top product of the Pfizer multinational corporation. In 2016, Viagra generated 1.56 billion USD of revenue. This drug has been in the pharmaceutical market for 19 years and still has not lost its selling position.

It is the most frequently prescribed medication for men with sexual dysfunctions. Multiple generic producers struggle hard to let Viagra copies enter the global pharmacy.

What makes Viagra so unique? Is it helpful for sexual problems only? Why is this drug world popular? Let’s discover all Viagra’s secrets today.

What Is Sildenafil?

Sildenafil is a chemical ingredient which is used for the treatment of sexual dysfunctions in men, caused by abnormal natural processes in the organism. It belongs to the PDE5 inhibitors drug family, the main principles of which are relaxing muscles and forcing blood circulation to particular body areas. Among erectile problems, this chemical cures pulmonary arterial hypertension (high blood pressure in lungs).

Sildenafil is manufactured for males and females in different product lines. Female products are used for treating sexual problems in premenopausal women and boosting libido. Its effect on women was discovered later and this subject is still undergoing scientific research.

Sildenafil is produced under multiple brand names. One of the most well-known is Viagra, through another famous brand name is Revatio. They all contain sildenafil in different dosages.
Sildenafil Dosages, Uses, Side Effects, Mechanism of Action

History

The familiar «blue magic pill» has a riveting history behind its invention. In fact, Viagra developers intended to create a drug for cardiovascular illnesses. In 1991, Pfizer concern workers tailored a chemical substance which belonged to the pyrazolopyrimidinone class and it was purposed to cure heart diseases (angina, chest pain, etc).

During the clinical researches under the leadership of Ian Osterloh, the significant effect of sildenafil in the treatment of the mentioned diseases was not found. But they examined an unexpected adverse symptom: improving and sustaining erection in males. Pfizer stopped heart illness investigations and concentrated on further research in penile erection.

Viagra pills

The names of the Pfizer Viagra inventors is a big secret that every worker of the company should maintain. At first, the British press was given the names of Peter Dunn and Albert Wood as responsible people for inventing the process.

Later in the same year, Andrew Bell, as well as doctors Nicholas Terrett and David Brown, proved the efficiency of sildenafil in an angina cure. Terrett was named in the patent document for the practicing of sildenafil in heart illness therapy, and he is known as «Viagra’s father». He says that indeed his command has discovered the genuine assignment of sildenafil, while P. Dunn and A. Wood developed a method of mass-producing it.

In 1994 continuing heart problems investigations, Terrett and his coworker Peter Ellis observed the working mechanism of sildenafil. A. Wood and P. Dunn continued working on the chemicals, too, taking part in a 9-step process to synthesize sildenafil into a pill. On the 27th of March, 1998, sildenafil was approved by the FDA.

Pfizer has not rewarded any particular inventor of sildenafil from the working command. Following the information that was given to American Press, Viagra’s inventor was recognized as the Senior Vice President of Medicinal Discovery of Pfizer, Dr Simon Campbell, who was responsible for the developmental process.

The Viagra product was a real booster of Pfizer income. Its profits have risen drastically after bringing the «blue pill» into the world pharmacy market.

In 2013, the Pfizer patent on Viagra ended in the countries of the European Union. That fact allowed generic producers to manufacture their own variations. They have been using the name «sildenafil» for their drugs, since the name «Viagra» can be used by Pfizer only. Therefore, today the pharmacy market can offer to ED sufferers both the original Viagra product of Pfizer production and multiple generic remedies which contain sildenafil and are characterized by equal action.

«The little blue pill» is a name peculiar to the Pfizer product only. Its generic copies are usually white and round. This visual difference of the tablets does not imply diverse medical characteristics. To receive market approval, generics must be absolutely bioequivalent to the branded drugs, as well as prove safeness and identical effectiveness.

Is It FDA Approved?

Production of sildenafil

Viagra is the first oral drug in the USA approved for impotence treatment. Sildenafil was marked as Viagra and Revatio, and it was originally approved by the FDA in 1998 and has been distributed in 120 countries. The original Pfizer patent will expire in 2020.

But there is an exception for a few companies. Based in Pennsylvania, Israel transnational Pharmaceutical Industries Teva has settled an agreement with Pfizer. In fact, Teva had been selling generic sildenafil since 2013 in Europe and had long court procedures with the original producer of «little blue pill». According to the agreement document, Teva company was allowed to produce generic sildenafil, paying a royalty to Pfizer through the expiration of the Viagra patent in the US. Generic sildenafil of Teva’s production has been launched since December 2017.

Mylan, one of the world’s leading generics and specialty pharmaceuticals company, has also created an agreement with Pfizer not to release their generic Viagra version until 2017.

At least nine generic producers have applied to the FDA to approve their version of Viagra. Successfully checked products will be able to participate in the global pharmacy market in 2020. Meanwhile, generic Viagra is available and has been successfully sold in Canada since 2012, and in European countries since 2013. The companies Teva and Actavis debuted generic Viagra in Europe.

Sildenafil Brands

The first patent expiration of Pfizer product ended in June 2013. That period was a party time for generic producers. According to data from The Guardian, approximately 20 generic drug makers lined up their version of generic sildenafil. Among these companies are:

  • Sandoz (Novartis company and a global leader in biosimilars);
  • Teva (multinational pharmaceutical company);
  • Accord (young and fast growing generic pharmaceutical industry in the UK and Ireland);
  • Ajanta (Indian multinational company);
  • Dr Reddy’s (Indian multinational pharmaceutical company);
  • Mylan (American global generic and specialty pharma registered in the Netherlands);
  • Actavis (global company that specializes on generic, over-the-counter drugs, and biologic products);
  • Torrent (the leading pharma of the Torrent Group, based in India);
  • Bristol Labs (young and fast growing British drug producer that specializes on generic medicines in Europe and the UK);
  • Zentiva (European manufacturer of modern high quality generics);
  • Ratiopharm (German pharmaceutical generics business);
  • Ranbaxy Laboratories (Indian multinational pharma industry);
  • Neuraxpharm (German manufacturer of generic medicines);
  • Cipla (one of the top global pharmaceuticals companies in India).

Sildenafil brandsRegardless of the brand, the molecular structure stays equal, as well as the absorption method, mechanism of action, side effects, and action of the metabolism. Color, shape, size, and consistence may vary, but these features do not impact the main principles of the drug’s work. The pills with the same strength but produced under different brands are very much like one another due to containing the same amount of each chemical agent. Licensed by the local government, products have passed the quality and safety tests which the state law demands. The scientific studies between drugs with the same dosage of active substance but produced by different manufacturers are absent and unnecessary.

As is so often the case, drugs go out of stock and that causes a big concern in patients. Absent of a particular medicine may happen because pharmaceutical companies cannot fill the wholesale orders from pharmacies or the drug was manufactured in small batches. No matter what the reason is, usually people get used to one trade name and are quite skeptical in situations when they need to switch to another. There should not be any fear though, as when choosing a licensed drug, a patient will guaranteedly get the promised effect.

Viagra and Generic Sildenafil – What’s the Difference?

Today the pharmacy market offers the original Pfizer Viagra and generic sildenafil in multiple form and dosages. The first thing which catches attention in the Viagra vs generic sildenafil battle is definitely the difference in costs. Generics’ prices are a lot cheaper (15-90%). The reasonable patient’s question is what is the difference between the two drugs and if the original Pfizer product is worthy of the money the manufacturer requires. Let’s check the factors that define the sildenafil and Viagra difference:

  1. Composition. The brand Viagra and generic sildenafil contain the same active substance, sildenafil. The minor compounds of the pills may be different, but it does not affect general drug’s work. Identical chemical structure guarantees the same working mechanism.
  2. Effectiveness. The vast majority of patients assume both drugs are equally efficient. Only a small percentage of users find the original product more powerful.
  3. Side effects. Most patients experience the same adverse events after taking the original and generic products. A very small number of males experienced different negative reactions after taking a generic interpretation. This fact may be explained by the different minor compounds.
  4. Price. As stated above, generics cost much less. A pharmacy coupon can help to economize, too.

This comparison is true only for generic preparations which were produced by reputable companies. Patients should avoid products of unknown manufacturers without a quality certificate attached. Mislabeled drugs may not provide the promised effect and make a damaging impact on the consumer’s health.

Difference Between Sildenafil and Sildenafil Citrate

SildenafilPatients may see the term «sildenafil citrate» and get concerned about what is the difference between sildenafil and sildenafil citrate. Sildenafil citrate is the patented active ingredient which Viagra has. Sildenafil is the short name of long Viagra chemical formula. Viagra’s medical subject headings (MeSH) are defined as:

  • citrate, sildenafil;
  • homosildenafil;
  • lactate, sildenafil;
  • acetildenafil;
  • desmethyl sildenafil;
  • hydroxyhomosildenafil;
  • NCX-911;
  • 1-((3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine citrate.

It means that definitions «sildenafil» and «sildenafil citrate» are synonyms.

Dosages of Sildenafil

The original Pfizer sildenafil comes in three doses: 25 mg, 50 mg, and 100 mg. The most convenient and frequently recommended one is 50 mg. It is a moderate dosage which can be decreased to 25 mg in case of annoying side effects, or increased to 100 mg in case of weak effect. Regardless of the amount of sildenafil, one dose must be taken only once a day. Increasing the dose independently without medical consultation is strongly forbidden due to individual health conditions and high risks of unwanted reactions.

The generic doses are designed for maximal customer’s convenience. There is sildenafil in dosages 20 mg, 25 mg, 50 mg, 75 mg, 100 mg, 150 mg, and 200 mg. The dosage of 100 mg is the most frequently used among customers due to good effectiveness and moderate side effects manifestations. Low sildenafil concentration (20 mg, 25 mg, and 50 mg) will be good for light sexual problems. Respectively, the doses 150 and 200 mg are recommended for the treatment of severe erectile dysfunction (ED) cases. They can be used if the lower dose 100 mg was well tolerated but showed weak effect.

The correct plan of cure must be prescribed by a healthcare provider in private order based on the patient’s general health condition and the level of current erectile problem. The doctor should estimate the important factors and state what is the normal dose for each particular case and how to use it.

Forms

Injections of sildenafilModern pharmacology offers sildenafil in multiple medical forms which makes the usage easy and convenient. The available products are represented in the list below:

  1. Classic rigid tablets. Film coated, not chewable drug that should be used along with a full glass of water. The form and color may vary depending on the manufacturer.
  2. Sublingual tabs and troche. The tab should be placed under the tongue and dissolved without water. The benefits of this form are a faster onset of action with a smaller dose plus quicker work of the drug due to quick absorption. It should be noted that this drug form is not approved by the FDA and is assumed as off-label preparation which may cause severe side effects.
  3. Effervescent dissolvable tablets. This is a unique formula of the tab which should be dissolved in the water to provide easy absorption and even more effect. Quick solubility and a delicious taste makes it easy to consume.
  4. Oral jelly. The remedies that look like a tasty dessert will be estimated by those who can not stand bitter rigid drugs or have difficulties with swallowing firm medicines. Various choice of tastes and consistency turn the medicine usage into fun which can be played in sex games with your partner.
  5. Capsules. Quick dissolving in the bloodstream, these capsules provide an awesome effect: capsules start working in 20-30 minutes.
  6. Liquid (oral suspension). Mainly used for curing pulmonary hypertension in kids.
  7. Topical cream. This unique formula will be especially estimated by those who cannot take sildenafil orally due to side effects or health conditions (angina or heart attack patients). The cream should be applied to the tip of the phallus. Once it is absorbed into the skin, the erection appears. Applying creme directly to the genitals diminishes side symptoms such as headache or dizzying and solves the specified erectile problem. This form is not approved by the FDA yet and is still in the developmental stage.
  8. Injections. The solution for injections is meant for the treatment of pulmonary arterial hypertension (PAH) in adults and those who cannot take oral drugs. 10 mg of injection equals 20 mg of the oral dose.
  9. Powder for oral solution (Sildenafil Mesylate). The form allows rapid absorption due to its dissolving in water for suspension making. Powder is also widely used for PAH treatment.
  10. Vaginal tablets. Used for improving uterine artery blood circulation in women undergoing in vitro fertilisation (IVF).

The variations of sildenafil are multiple, and the drugs may be named differently. It exists in the pure state and in combination with other ingredients. A patient should pay attention to the active ingredients. Mixed preparations contain different doses of the chemical agents. A few examples of pure and mixed sildenafil are represented in the table.

Pure sildenafilIn the mix with the ingredients
Kamagra

Cenforce, Super P-Force (Viagra Super Active, sildenafil and dapoxetine)

Vega
Nizagara
Caverta

Malegra-FXT, Viagra Super Fluox-force

(sildenafil and fluoxetine)

Zenegra

The strength of the drugs vary, too. There are enhanced formulas of pure sildenafil (like Sildenafil Professional) which have a longer time course and prolong erections up to 6-8 hours, providing an even more powerful effect.

There is also a special line for women that cures female sexual arousal disorders and helps females to achieve orgasm. These drugs showed good results during clinical trials, though the proper scientific research goes on.

Who Can Use This Medicine?

Cases of uncommon sildenafil usesViagra is a famous medicine for men with ED problems. Along with sexual dysfunctions, it can help with other ailments, too. The medicine can be taken by males and females, and it is cautiously used in children. The science news registered the following cases of uncommon sildenafil uses:

  1. Diabetes and gastroparesis. Scientists of Johns Hopkins Medicine in Baltimore, Maryland discovered that by relaxing the stomach tissues, sildenafil helps to prevent digestion process slowing, anorexia, and dehydration.
  2. Altitude-related lung disorders (altitude sickness). German scientists found out that alpinists who received a dose of Viagra could endure a lack of oxygen in the Himalayan mountains.
  3. Angina attack. Iceland academic researchers ascertained that sildenafil may disable the gene that prevents blood vessels from widening and leading to a major stroke risk.
  4. Cardiac distress. Due to widening blood vessel function, sildenafil allows physical exercising and sexual activity to normalize blood pressure and heartbeats.
  5. Female sexual disorders. Sildenafil helps to stimulate bloodflow to the female genitals, increasing sexual satisfaction during intercourse.
  6. Sterility. An overly thin uterine lining is one reason for female sterility. Sildenafil allows the enlarging of the uterus lining through dilation of the blood ways.
  7. Premature birth. England doctors gave sildenafil to a baby born on the 24th week of pregnancy. That helped to open arteries for heart treatment through the pulmonary artery, excluding lung disease.
  8. Pregnant women who suffer from intrauterine growth restriction (IUGR), a state when a baby in the womb does not develop normally. The retardation of fetal growth may cause various problems during the pregnancy or after birth. Increasing the bloodflow in the genital area, sildenafil may help by supplying more oxygen to the placenta. The studies go on.

Sildenafil for ED

Sildenafil is widely used in ED treatment for men. The American Urological Association recommends first to deduce the reasons which caused the erectile problems. They may be a sign of diabetes or cardiovascular diseases, particularly heart or blood pressure problems. Depressive states and problems with partners may also impact sexual ability. A patient should bear in mind all the drugs he has been taking. Some antidepressants, heartburn and blood pressure medications, or analgesics may cause ED as an adverse symptom.

When the ED problem is diagnosed by a urologist, a patient can apply for sildenafil therapy. Its efficacy and safety has been tested in numerous studies, and it is the most frequently prescribed drug since its side effects have been studied in detail.

Discovering the nature of ED in a patient is very important for successful treatment because Viagra’s action does not cover physiological states. It is somewhat helpful in stressful conditions and boosts the feeling of self-confidence in a man. But sildenafil does not cause sexual desire, it only helps to achieve and maintain an erection.

Many males all over the world have had an effect from Viagra and widely use it for random or regular treatment. Those who might get information about Viagra from unofficial sources may dismiss it as a lifestyle drug or one with little medical importance. In fact, this is a serious medication which should be prescribed for individuals. It works on the phallus arteries and may provoke various side effects. Therefore, a personal healthcare provider recommendation is necessary.

Is It Used for Pulmonary Hypertension?

Pulmonary hypertensionPAH is a group of diseases in the narrow state of arteries which transport blood from the heart to the lungs which is characterized by heart overwork. It may lead to right ventricular failure and premature death.

The function of sildenafil consists in relaxing the arterial muscles and broadening the arterial channels. The result of the therapy is easier bloodflow, proper supply of the lungs, and improved ability for physical activities.

Pediatric use of sildenafil caught close medical attention. During a small clinical trial, 14 kids aged 1-17 y.o. with PAH were tested. After 6 months of usage, the walking distance increased (which proves an increase in physical ability), without major adverse symptoms. The allowed doses of sildenafil in kids are low (10 mg) and medium (10-40 mg).

In August 2012, the FDA announced a strong warning against using sildenafil in children, justifying this by the high level of mortality in kids after high doses and ineffectiveness of low ones for PAH therapy.

In response, clinical pediatric PH experts put forth a consensus statement with cautious use of low and moderate doses of sildenafil in children and strong warning to avoid high ones.

The problems of sildenafil for PAH therapy today is a lack of evidence, despite several experimental reports and numerous medical articles. The medical community eagerly waits for more clinical studies and answers for the questions of whether or not sildenafil can be used in long-lasting therapy and which doses are recommended. Generally PDE5 inhibitors appear to be an attractive and effective addition for curing this devastating orphan illness.

Sildenafil for BPH

Many men face erectile and large prostate problems at the same time with age. These diseases are caused by different issues, though in some cases the therapy of BPH may cause ED. Scientific research has proved that effective ED drugs, including sildenafil, may have a powerful positive impact, reducing the symptoms of BPH.

The meaning of sildenafil in the BPH cure has been studied for four years. The prostate is a gland at the base of the bladder which is responsible for producing spermatic fluid. When BPH starts its progress, a patient has urination problems. Sildenafil helps to relax muscle cells, making urination easier.

During clinical trials of the most popular ED drugs, sildenafil, vardenafil, and tadalafil were checked in 1000 men with average and severe forms of low urinary tract symptoms over 8-12 weeks. Daily usage of PDE5 inhibitors have had a positive impact upon results. ED therapy in BPH is assumed to be safe and effective.

It should be noted that long term usage (6-12 months) and interaction between ED and specific BPH drugs demand more scientific research. As far as the parallel intake of alpha blockers and ED drugs may significantly lower blood pressure, the combined therapy should be elevated. The costs for ED drugs are not covered by insurance for BPH treatment, and that factor should be counted as well.

Can Sildenafil Be Taken Daily?

SexPatients with chronic ED may wonder, can sildenafil be taken daily? For Viagra, a 25 mg is a dosage appropriated for daily usage. Usage of sildenafil on a daily basis has gathered contradictory opinions. Some scientists claim that there is no need to take it if a patient does not have sex every day. Sildenafil does not possess accumulative features and does not recover the phallus tissues but only stimulates them to plan for very soon sexual intercourse.

Moreover, daily usage may cause psychological dependence. Without sexual stimulation, chemical processes after taking sildenafil do not happen, but a man starts to feel more confident. If a man think, that only this drug makes him sexually strong, it can lead to emotional dependency.

According to the opinion of professor Irwin Goldstein of Boston University, daily Viagra usage is a good preventive course from possible ED problems. It is based on a small study during which 30 men used a small dose of sildenafil every night and marked the awesome effect of it. The international medical community has highly criticized this point of view.

The effective drug approved for daily usage may be called Cialis (tadalafil), available in 2.5 mg and 5 mg. These doses have multiple advantages: acting within 15-20 minutes after consumption and maintaining a positive effect up to 36 hours. It is well-tolerated and compatible with alcohol and does not cause addiction.

As a whole, daily usage of Cialis also helps to:

  • overcome premature ejaculation problem and increase libido;
  • struggle with bacterial and infectious agents;
  • increase viruses resistance;
  • improve blood vessels condition;
  • normalize testosterone production;
  • improve the quality of seminal fluid;
  • restore microflora of the genitals;
  • prevent unexpected stress.

Is It Safe?

ErectionMultiple assessments dedicated to the question is sildenafil safe were all successful. During one of the trials, 1008 patients with ED dysfunction were recruited and received doses of 25-100 mg during 36-52 weeks of studying. In 36 and 52 weeks, 92% and 89% of men had felt improvement.

In results all criteria were marked, such as the duration of sexual intercourse, rigidity of erection, general level of satisfaction, and the frequency of stimulated erections. Among the most common adverse symptoms noted were headache, blushing, upset stomach, and nasal problems in soft or moderate form. Long lasting therapy does not detract the effectiveness of sildenafil in patients with ED.

The clinical trials warn that sildenafil should be cautiously used in cases of heart failure or acute myocardial infarction or stroke diagnosticated up to 6 months ago. Parallel use of nitrates containing drugs (glyceryl trinitrate, isosorbide dinitrate) is unsafe. Sildenafil is perilous for patients with unstable angina pectoris. In the absence of contraindication, sildenafil is extremely suggested for ED cure.

Existing evidence proves high effectiveness and well toleration of sildenafil in males with ED and spinal cord injury, urinary tract symptoms benign prostatic hyperplasia (BPH) with concomitant ED, and for pulmonary hypertension cases in severe form (including children). Uses for women demand more scientific research.

How to Take Sildenafil Pills for the Best Results?

Sildenafil is an effective, powerful, and well-tested drug which improves ED problems in most cases. Those who did not feel its effect obviously have made several mistakes in therapy course. To achieve the best results from the medicine, it is extra important to have a clear understanding about how to take the pills correctly. To receive the maximum effect from the drug, ED patients should avoid the most common mistakes that cause the failure of the drug:

  1. Lack of information. 69% of patients do not receive a proper medical consultation before starting the treatment course. Sildenafil must be used only after a complete medical examination of general health condition at a medical center and receiving an individual prescription. The healthcare provider should tell a patient detailed instructions: what is sildenafil, how it works, when to take, and how to take it. The drug should be used strictly in correspondence with the given directions.
  2. Lack of sexual stimulation. Do not expect a miracle to happen. 3% of males still think that after taking the «magic blue pill» the erection appears in a simple way. That is a false belief. Sexual mood and stimulation are the necessary factors that activate the chemical processes in the organism, leading to the erection. Without foreplay, touches, tastes, and smells, reaching sexual excitation and a rock hard erection is impossible.
  3. Low dose (happens in 31% of patients). Doctors usually prescribe a minimal dosage in the beginning of the course to reduce side effect manifestations. Sometimes it is enough for treating ED, sometimes it is not. In case a patient did not feel the effect, it makes sense to talk to a medical representative about increasing the dosage (if the patient’s health condition allows that). Taking an enlarged dose independently is prohibited and risky due to unwanted negative reactions.
  4. Taking the drug after a meal. Over 20% of the head counts showed that patients take the drug after a square dinner. In fact, the drug works best on empty stomach or at least after a light snack. That is caused by the indigestion process which slows down how sildenafil works. Those who have had a good feed should wait to take sildenafil for 2-3 hours.
  5. Let the drug start working. Eager patients should remember that the remedy starts working within an hour after consumption. Some sildenafil versions start working sooner, in half an hour or so. Nevertheless, there should be a time period before consumption and sexual act. Do not hurry up; use your spare time advantageously for fantasies, sexual conversations with your partner, and foreplay!
  6. Test a few dosages. It often happens that sildenafil does not work the first time. But 33% of males stop taking the drug after the first failure. A patient should not lose hope and take more doses later according to the treating scheme up to 5-6 times, remembering that the next consumption might be taken in the next 24-hours period.
  7. Try another drug. Every patient responds differently to the medicines. If all methods mentioned above appeared ineffective, that does not mean that this ED problem is an incurable disease. It makes sense to try other pills of identical action but with a different active ingredient, for example Levitra (vardenafil) or Cialis (tadalafil).

What Happens if I Overdose?

Watch carefully how much sildenafil you consume. If the sildenafil dosage was taken high in value, the symptoms will be seen within few hours after the drug consumption. Usually they are manifested as side effects.

Blurred vision

Among the most common overdose reactions are:

  • sudden blood pressure drop (high or low) which leads to fainting;
  • priapism (abnormal long-lasting erection during 4 hours and more);
  • blurred vision or sudden loss of sight;
  • abrupt hearing loss;
  • complications from the side of kidney and/or liver work;
  • bleeding;
  • physical deformation of the secondary sex organ and permanent impotence;
  • stroke or heart failure.

The need for medical intervention depends on the manifestation of the side effect and how long does it last. In case of rapid negative health changes, a patient should contact local hospital personally for emergency treatment immediately. The therapy of sildenafil overdosing may be different depending on the situation. The intensity of the symptoms might be lowered by other drugs or medical methods.

It is always better to exclude such incidents by following the rules and a dosing regime of sildenafil consumption. Do not start taking sildenafil if your health condition does not allow it.

Sildenafil Mechanism of Action

To better understand the purpose of sildenafil and how does it work for ED, it is necessary to know how an erection appears. The penile erection is defined as a state caused by blood pressure which flows to the phallus, enlarging it and providing rigidity. An erection may appear in sleep and awaken a man’s condition.

For successful penetration, the phallus must be erect. In healthy men, the nervous, arterial, and vascular systems are in order, so a man easily becomes erect after sexual stimulation. For men with ED problems, achieving erection appears to be complicated. And Viagra is able to help here.

Since massive bloodflow to the penile area is a necessary condition for an erection, the function of sildenafil consists in increasing blood circulation to the genital area. When a man is in a sexual mood, his brain sends messages through the nervous system and blood starts flowing to the phallus. Patients should remember that Viagra is neither an aphrodisiac nor a hormone. A single tablet without sexual stimulation is helpless.

The psychological factor is very important in the mode of action because it impacts many chemical reactions in the organism. When a man is aroused, his body starts releasing nitric oxide in the erectile tissues, the two parallel changes at the sides of the phallus. Nitric oxide, in turn, brings into action the ferment guanylate cyclase, increasing levels of cyclic guanosine monophosphate which is responsible for erectile function.

Belonging to the PDE5 inhibitors class, sildenafil blocks the chemical phosphodiesterase type 5, which prevents a healthy erection. Among blood flowing, sildenafil intensifies the effect of nitric oxide by blocking PDE5 and increases the levels of cyclic guanosine monophosphate. As a result, the smooth muscles of the phallus receive enough relaxation and proper bloodflow, the excellent conditions for an erected state.

Understanding the action is not enough, and every patient should know how long does it last. The drug has an elimination half-life of 4 hours (working time) and 5.5 half-lives. This means that one dose of sildenafil stays in your system approximately 22 hours in a whole. The elimination period depends on such individual features as age, food, alcohol consumption, general health state, taken dosage, and much more.

Contraindications

High popularity of the famous Viagra has changed to abuse in the past few years. It happened mostly because of men ignoring the rules of sildenafil administration, and, as a result, side effect manifestations in them.

Viagra is not «magic» for everyone, as contraindications still exist. There are categories of males who cannot use this drug.

Contraindications

Among them are males who:

  • have not reached the age of 18 y.o.;
  • are prohibited to have sexual life due to weak cardiovascular health;
  • have circulatory system problems (thrombocytopenia, leukemia, hemophilia);
  • consume nitrates, organic nitrites and nitric oxide donors;
  • suffer from hepatic and renal ailments in severe form;
  • experience hypotension or hypertension;
  • have had heart attack or stroke during the last 6 months;
  • suffer from retinal diseases;
  • have long-lasting and painful erection (priapism) propensity or phallus deformity;
  • sustain bleeding illnesses.

Highly allergic individuals should be very cautious while taking sildenafil, because it may cause negative reactions or chronic poisoning complications.

The list of diseases is represented for review and is far from complete. Consult a private healthcare provider regarding every particular medical condition.

Sildenafil Side Effects

Most drugs cause side effects, and sildenafil is not an exception. Clinical trials report about mild and average unwanted reactions. Severe forms of side effects are registered rarely. The table represents the classification of the most frequent adverse events.

Major symptomsMinor Symptoms
CommonRareCommonRare
Urinary bladder painSevere and / or counting migraineMuscles achePain in stomach or abdominal
DisturbanceCough
Behavior changes similar to alcohol intoxicationDisquietude
Gibberish speechPursinessBleeding from the bottom
Disorientation
Muddy or bloody urineConcentration difficultiesNightmares
Nervousness
Frightening dreamsBlushing
Urinary frequencyBroken sleepEarache
Fainting
Dizziness, especially when getting up suddenly from lying or sittingUrination at night
Sleepiness
ChillingOversensitivity of eyes and face bones
Painful urinationAgueSickness
Sweating
FeeblenessEntotic sounds
FatigueSneezing
Eye bleeding
Heat sensation in stomach or chestWeak visionIncreased salivation
Blurring of vision
Blue visionDifficult swallowing
Ambiopia (double vision)Bloody nose
Eye dryness
DyspepsiaEye acheStomach cramps
Sensation of something in the eye
Eye redness, itchingSore headPuke
Shades of colors
Light sensitivity
VertigoTemporary loss of sightTongue redness or irritation
Bone pain
Hands numbnessDigestive troubleLimbs numbness or tingling
Lower back or side pain
Swollen joints
NumbingMuscles twitchingSore mouth, lips
Cramps, seizuresNasal congestion or runny nose
Excessive hungerHypersensitive skin
Sickness
Thirst
ItchinessFast, irregular heart rateShaking
Hard breathingWarm skin
Sore throatDrowsiness
Loss of hearing
Pale skin
Prickly sensationSkin rash, itchPoor sleepOrgasm failures
Ulcers on skin
Cutaneous lesionAsthma exacerbation
Skin stinging
Long-lasting painful erection

Not all medical states from the list above require medical help. Most side effects disappear as soon as the body gets used to the new drug. A medical representative may suggest methods of avoiding unwanted reactions.

If the events are continuing and bothering, medical consultation is highly recommended. After a medical examination, a medical representative may decrease the dose or reject the preparation intake.

Interactions

Blood pressureA patient should always inform his consulting physician about all other medicines he has been taking, including OTC (over-the-counter), recreational drugs, herbal remedies, and dietary supplements as they may interact with sildenafil.

Here are the drug classes which are strictly forbidden for co-administration with Viagra:

  1. Nitrate drugs, for example nitroglycerin (Nitrostat), isosorbide dinitrate (Dilatrate-SR) for angina or other heart problem cures. Recreational drugs (amyl nitrate or nitrite) also contain nitrates. Combined intake with sildenafil leads to critical blood pressure drops.
  2. Alpha-blockers. Combination of these drugs with sildenafil decreases blood pressure.
  3. Other preparations for ED (Cialis, Levitra, Stendra). Interactions lead to overdosing symptoms, multiple side effects, and priapism.

A few preparations that are forbidden for joint usage with Viagra are below:

  • Bosentan (Tracleer);
  • Cimetidine (Tagamed);
  • Imatinib (Gleevec);
  • Hypericum perforatum (St. John’s wort);
  • Nefazodone (Serzone);
  • macrolides: erythromycin (EryPed 200, EryPed 400), clarithromycin (Biaxin); azithromycin (Zithromax);
  • antifungal drugs: itraconazole (Sporanox), fluconazole (Diflucan);
  • heart and blood pressure preparations amiodarone (Pacerone, Cordarone, Nexterone), amlodipine (Norvasc);
  • drugs for hepatitis C cure: boceprevir (Victrelis);
  • protease inhibitors for HIV/AIDS treatment: atazanavir (Reyataz), ritonavir (Norvir), amprenavir (Agenerase);
  • medications for curing of seizure: fosphenytoin (Cerebyx), carbamazepine (Tegretol);
  • tuberculosis drugs: Isoniazid.

Is It Allowed to Take Sildenafil with Food?

Ideally, sildenafil should be taken on an empty stomach. By eating high fat meals, a man is more likely to gain weight which only worsens erectile problems. It is recommended to avoid fried and junk food. Best of all is eating low fat foods during the whole day when a man is planning to consume sildenafil.

According to the U.S. National Library of Medicine website PubMed Health, sildenafil may be taken regardless of meal time. A patient should avoid high fat meals because they slow down digestion processes and delay the start of Viagra work. They suggest taking sildenafil 1 hour before or during a meal compared to ordinary digestion of duration in 30 minutes-1 hour before planned sexual intercourse.

Grapefruit and grapefruit juice are worthy of special attention. This fruit impacts the work of all drugs, including Viagra. Preventing breakdown of the chemical agent in the organism, grapefruit provokes its greater uptake. It leads to high concentration of the drug in the blood and, as a result, various side effect manifestations. It is better to exclude this product out of daily ration while a patient is on Viagra treatment.

Alcohol Drinks

Alcohol drinksMany health experts warn men against taking alcohol during a Viagra treatment course. It threatens severe side effects manifestations. Nevertheless, many patients ignore this important rule. Some men even wrongly think that it helps to enhance sexual desire.

In fact, both sildenafil and alcohol have similar feature: they widen blood vessels. Their mix may lead to blood vessel dilation and may provoke such side symptoms as:

  • lightheadedness which increases risks of traumas;
  • fast and irregular heart rate;
  • blood pressure drops.

Among unwelcome interactions with Viagra, large amounts of alcohol worsen erectile problems, which is usually a result of much more serious health problems (like cardiovascular illnesses) which are not compatible with alcohol, either.

Alcohol affects the erection process. In addition to a hangover and a sore head, it complicates the natural erection process, reducing effectiveness of the drug and making sexual activity impossible.

If a patient’s health is good and stable, the appropriate dose of light alcohol drinks (wine or beer) is no more than 2 units. This fact should be discussed with a personal medical representative in private.

Intake with Other Drugs

Not all drugs should be rejected during a course of sildenafil. It can be taken with Rx and OTC drugs after a preliminary medical consultation. In most cases, a patient is prescribed a personal scheme of cure.

The table represents a few examples of co-administration of sildenafil with other drugs. Potential for serious interactions medications demand regular medical monitoring or alternative drug. Significant interactions require a doctor’s monitoring. Minor interactions are not significant.

Serious interactionsSignificant interactionsMinor infractions
DrugEffectDrugEffectDrugEffect
Alfuzosin (Uroxatral)HypotensionZafirlukast (Accolate)Sildenafil increases the effect of zafirlukastCarvedilol (Coreg CR)Low blood pressure; increased sildenafil effect
Boceprevir (Victrelis)Hypotension, syncope, eyesight problems, priapismButabarbital (Busodium)Butabarbital decreases sildenafil effectFluvoxamine (Luvox CR)Fluvoxamine increases sildenafil effect
Carbamazepine (Tegretol XR)Decreases sildenafil effectVerapamil (Verelan)Sildenafil increases the effect of verapamilSapropterin (Kuvan)Low blood pressure
Doxazosin (Cardura)Doxazosin increases effects of sildenafilCrizotinib (Halkori)Crizotinib increases the levels of sildenafilLabetalol (Trandate)Sildenafil increases effects of labetalol
Ketoconazole (Nizoral)Ketoconazole increases the level of sildenafilDabrafenib (Tafinlar)Dabrafenib decreases the level of sildenafilLabetalol iv (Normodyne IV)Labetalol iv increases effects of sildenafil

Comparison

Erectile dysfunctionED is a widespread form of sexual dysfunction in males. PDE5 inhibitors are the first-line treatment for these cases. Multitudinous clinical tests and studies have constituted the reliability and effectiveness of these drugs in ED problems.

Sildenafil was the first approved drug for this purpose. Later, new agents with other pharmacokinetic profiles and new formulations were marked. Traditional «on-demand» consumption evolved to a daily one. The progression provides more adaptability in an ED cure for patients and medical staff.

PDE5 inhibitors showed excellent results in symptomatic treatment of BPH and hypertension. Thusly, the elaboration of this drug class is acclaimed and highly influential in medical experience.

The most popular and efficient medicines for ED cure:

  • sildenafil (Viagra);
  • tadalafil (Cialis);
  • vardenafil (Levitra);
  • udenafil (Zydena);
  • mirodenafil (Mvix S);
  • avanafil (Stendra).

As far as they all belong to one drug class, the mechanism of work is similar. The difference consists mainly in the regime of taking and the clinical effect, respectively. The table below represents the distinction between medicines that are purposed for daily usage and on an as-needed basis. Choosing the preparation for yourself, you should pay attention at these important factors.

Variable qualityDaily usage drugsAs-needed basis drugs
Time limit for sexYesNo
Periodicity of sexAnyFor high frequency
Peak plasma concentration of the active substanceSufficientMay be not enough if a patient fails the regime of treatment
Risk of side effectsHigherLower
Costs for treatmentComparatively lowerHigher
Advantages on lower urinary tract symptomsDiscontinuouslyInvariably

Levitra Vs Sildenafil

Both Viagra and Levitra are effective medications for ED treatment. However, every patient should decide for himself which one he would like to use. The choice can be easily made on the basis of the most important factors which are represented in the table below. If the chosen preparation appeared ineffective or provided annoying adverse symptoms, a patient can easily switch it to another drug.

CriterionLevitraViagra
Active substanceVardenafilSildenafil
Brand ownerBayer Corp., distributed by GlaxoSmith KlinePfizer
FDA approved20th August, 2003March 27, 1998
GenericsVardenafil hydrochlorideSildenafil citrate
Dosages2.5 mg, 5 mg, 10 mg, 20 mg, 40 mg, 60 mg20 mg, 25 mg, 50 mg, 75 mg, 100 mg, 150 mg, 200 mg
Starting dose10 mg50 mg
Sales claimWorks faster, treats the cases where Viagra was helplessExists in the market 5 years longer than Cialis and 7 years longer than Levitra
Non prescriptionNoNo
When to take60 minutes hour before sexAt least 30 minutes before sex
Working timeUp to 8 hours4-5 hours
Half-life4-5 hours4 hours
Medical purposeTreatment of ED problems
Drug glassPDE5 inhibitors
Drugs interactionNitrates, alpha-blockers and more
Side effectsStuffy or runny nose, migraine, indigestion, vision changes, blushing, priapism
Consumption instructionsRegardless of meal time
Allowed frequency of takingOnce in 24-hours period
Storage15-30°C

Is Cialis (Tadalafil) Better?

Cialis and Viagra are tailored for ED treatment. Although these medicines belong to one drug family, they have significant differences. Viagra acts quicker, a patient feels its effect within half an hour after the pill consumption. Cialis may take up to 2 hours. A patient should choose only one drug and should never take tadalafil and sildenafil together. Duplicate treatment may become a reason for priapism and other side effects.

CriterionCialisViagra
Active substanceTadalafilSildenafil
Brand ownerDeveloped by Ocos, marketed by Eli LillyPfizer
FDA approvedNovember 21, 2003March 27, 1998
GenericsTadalafilSildenafil citrate
Dosages2.5 mg, 5 mg, 10 mg, 20 mg, 40 mg, 60 mg20 mg, 25 mg, 50 mg, 75 mg, 100 mg, 150 mg, 200 mg
Sales claim«Weekend pill» with action up to 36 hoursThe first ED pill in the pharmacy market
Non prescriptionNoNo
Working timeUp to 36 hours4-5 hours
Half-life18 hours4 hours
Allowed frequency of takingOnce in 24-36 hours periodOnce in 24-hours period
Side effectsBlushing, chest pain, stuffy nose, vertigo, hypotensionBlushing, migraine, stomach upsets, blue vision
Drugs interactionAlpha-blockers, nitrates, hepatitis C, tuberculosis medications, and moreNitrates, alpha-blockers, and more
Medical purposeTreats ED and pulmonary heart disease
Drug glassPDE5 inhibitors
Consumption rulesRegardless of meal time
Storage15-30°C

Natural Sources of Sildenafil

Ginkgo bilobaDespite the advantages of sildenafil, its working time is limited. To prolong the result, a patient should take more and more drugs. Luckily, nature has provided alternatives used since ancient times before the invention of Viagra. Those who aspire to avoid ED in the future or sustain light forms of it should try using the following substitutes:

  1. Muira Puama. This pristine herb grows in the Brazilian Amazon rainforests and got the nickname «potency wood». All parts of the plant are aphrodisiacs, increase libido and improving ED symptoms without unwanted reactions. The herb was tested in 1994 by medical sexologist Dr. Jacques Waynberg. During 2 weeks, 262 men with ED symptoms received 1-1.5 g of the moire puma extract. 62% valued the therapy as functional and 52% as curative. Research notes that only alcohol infusion on the base of the plant provides results in curing ED. Due to the insolubility of the components, powdered drugs (capsules and tablets) are not efficient.
  2. Ginkgo Biloba. The National Chinese tree grows in Korean and Japanese forests. Local people eat the nuts for an aphrodisiac. Ginkgo Biloba’s leaves increase blood circulation. During clinical tests, it showed benefits in 78% of tested men with impotence and good blood supply to the genital area. The duration of the cure lasts up to 3 months. The remedy does not have side effects.
  3. Maca Root. A world-famous plant that grows in the high mountains of Colombia, Peru, Chile, and Bolivia. This effective energy enhancer was applied to sexual problems, prostate and cognitive diseases. It increases fertility and provides relieving effect on females in the menopausal period. Thought its results are not as fast as Viagra’s, the effect is long-term and lasts after treatment. Alcohol infusions show the best therapeutic results.

The plants which demand more scientific evidenc are yohimbe, horny goat weed, and red ginseng. Although, all natural remedies do not have immediate effect, this way of treatment is safer for general health. Before taking any natural aphrodisiacs, the preliminary consultation with a naturopath is highly recommended.

Some powerful foods act like Viagra and can boost the sex drive, too. The components in natural foods are absolutely safe and do not require dosages. For a stronger erection, it is healthy to eat:

  • watermelons;
  • eggs;
  • walnuts;
  • spinach;
  • bananas;
  • dark chocolate;
  • avocados;
  • pomegranate;
  • asparagus;
  • cardamon.

It should be noted that healthy components in food may help to prevent possible erectile problems but scarсely can cure the existing disease.

Sildenafil Reviews

Viagra is a world-famous drug. It has been widely used by men all over the world and most patients stay satisfied with the results. 73 y. o. patients feel like 23, and some of them noticed an absolute absence of side effects. The price stays a meaningful question, which actually can be successfully solved by generics.

Rating diagram of Viagra

Side effects remain questionable. The diagram below represents the most frequently discussed themes in the Internet about sildenafil, concomitant diseases, and side symptom estimation. The total rating of Viagra is 4.4 of 5 which means that people are satisfied with this drug.

Such adverse effects as nasal congestion, headache, and blood pressure drops are well-known and scientifically marked. Viagra does not cause skin cancer (melanoma), as was proved during a clinical trial. Patients should appeal for medical consultation regarding any health condition. It is very likely that your fears are groundless.

Effectiveness and Benefits

The effectiveness of sildenafil was proved during multiple scientific studies. The treatment was efficient even in severe ED cases. Despite a long existence in the pharmaceutical industry, this drug has not lost its popularity. Millions of patients are satisfied with the results and choose sildenafil for regular usage. Such popularity is absolutely deserved.

It showed amazing results not only in restoring sexual function, but in PAH, heart diseases, mountain sickness therapy, and Raynaud’s phenomenon. Its effect in females with sexual dysfunction and pregnant women shows that all sildenafil benefits are not discovered yet. Clinical tests go on, and maybe soon we will know about more advantages of this «magic blue pill».

Where and How to Buy Sildenafil Without Prescription?

Purchasing in online shopThe next question for patients who have chosen sildenafil for an ED cure is where to buy it. Viagra is sold in any local pharmacy. Be ready to provide a prescription to the pharmacy representative and pay extra money because the price for sildenafil is not covered by state insurance. The original Pfizer product is not a cheap drug.

The cheapest option is to order the medicine from Indian drug stores. Here come a few problems, too. A purchaser should be sure that he buys a product of high quality. The investigations might take some time, and the result may be unpredictable. There are possible problems at the custom services because FDA laws are very skeptical about all incoming drugs.

Our online pharmacy CialisBit offers the most convenient way of purchase. In our drug store, sildenafil is represented under different trade names. Also, you can find many other preparations for treatment and regular cure of erectile problems and premature ejaculation (Cialis, Stendra, and many more). In our pharmacy, you can buy any drug without prescription.

We sell only high quality generics at a fair price. All medicines come from our Indian laboratories and are sent through the US within 7-18 days. Quick shipment, payment, and big discounts (-35%) for Bitcoin payment are the benefits of online order in our chemists. Cure your delicate problems professionally at the most favorable prices.

Dapoxetine Uses, Side Effects and Reviews

Dapoxetine Uses, Side Effects and Reviews

Premature ejaculation is a serious problem for many men all over the world. Most of them do not discuss it with doctors, instead blaming transitory circumstances or falling into depression, without any reason for either. Is there an easy, safe, and quick cure for this male problem, and how does it work? The answer is in this dapoxetine review.

What Is the Dapoxetine Drug?

Created in the labs of Eli Lilly and Company, it was considered to be useless for a long time before its curative virtues were discovered. In 2004, dapoxetine was submitted to the US Food and Drugs Administration as the natural remedy for premature ejaculation. It was the first pharmacological treatment for PE. In our days, dapoxetine belonged to Johnson and Johnson, and it is marketed in some European and Asian countries, Latin America, and New Zealand under different trade names:

  • Priligy — the most popular brand approved and distributed by different companies in Eastern Europe, Great Britain, Ireland, Portugal, Switzerland, Spain, Finland, France, Italy, Germany and other European countries, South Korea, Singapore, Malaysia, Thailand, Hong Kong, New Zealand and Mexico;
  • Dasutra, Kutub, Xydap, Sustinex, Duratia are the not full list of trade names of dapoxetine tablets produced and commercialized in India;
  • Lejam is the drug manufactured in Saudi Arabia and Joypox — in Egypt;
  • Prolongal, Lagose, Precoce and Extensil are Argentinian medicines;
  • and other trademarks and generic names, such as Westoxetin, Pentenal-30, Dapoxetine Hydrochloride etc.

In our online pharmacy, we offer pills of the highest effectiveness and fairest price. There are combo trial packs available, where everyone can order from 100 to 1000 tablets in any combination of the most popular drugs, such as Viagra, Cialis, Female Viagra, and Priligy 60 mg. This is the best offer to try medicines and choose the most efficacious for beneficial price and with free shipping.

Dapoxetine Uses, Side Effects and Reviews

FDA Approval

According to American standards, there are four phases for the clinical trials of drugs. When the new medicine passes the first three of them, it usually gets the approval of the medical authorities for use in the country. This process of development of the drugs takes many years. Phase IV is the studies that take place after the drug is certified for marketing.

Dapoxetine is in the third phase trials since 2003. It was applied for approval by the FDA in 2004 as dapoxetine hydrochloride, but in 2005, it was rejected. There were two more testings conducted in 2006 and new applications to FDA, but American administration has certain concerns about the side effects. There is a hope, though, that soon dapoxetine will be approved for production and marketing in the USA.

Anyway, any American user can acquire this remedy in India, Europe, Egypt, or Mexico. CialisBit suggests the easiest decision for this issue, as anyone can get the necessary medication online from the world-famous producers completely legally with the guarantee of high quality and safety.

Forms and Dosages

Super P-Force pillsAll listed above dapoxetine drugs are manufactured in the form of firm-coated tablets with different active ingredient contents. Tablets that contain pure dapoxetine have 30, 60, and 90 mg of it and are sold in packages from 20 to 500 tabs. Dapoxetine hydrochloride exists in liquid form, as it is sold only for research purposes and cannot be used as treatment for humans.

There are also pills that combine medications for erectile and ejaculation maladies:

  • Tadapox is the brand name of the combination of 60 mg of dapoxetine and tadalafil 20 mg;
  • Super P-Force, or Super Viagra, and Sildigra Super Power are the brands of pills with 100 or 50 mg of sildenafil and dapoxetine 60 or 30 mg available for sale;
  • vardenafil and dapoxetine are the components or Super Zhewitra, Super Levitra, Super Valetra, Snovitra Super Power and others.

The optimal measuring for a single use is 60 mg, but the patient can change it depending on the response of the organism to the initial dose.

Who Can Use Dapoxetine HCL?

Dapoxetine hydrochloride is the SSRI inhibitor, and one of the properties of this medicament is its quick operation and quick elimination in the blood. This quality makes it the best for pharmacological treatment of PE. Who needs it? Obviously, men with rapid ejaculation observed on regular or constant basis.

The average man’s ejaculatory time is 4-8 minutes after penetration. This parameter varies from man to man and from sexual act to sexual act, but there is the common opinion in medical science that the term premature should be used in cases when men have orgasm and emits semen as soon after the beginning of sexual intercourse as one minute or less. The International Classification of Diseases has the concrete indicator of 15 seconds. Sometimes the rapid semen emission comes even before the penetration.

How and When to Take Dapoxetine Pills?

Man takes pillAs the causes of PE are not clearly determined yet, and there can be many reasons for it, the decision if there is a need to take medication must be done carefully but without procrastination. One time rapid orgasm can be explained by extra excitement or sexual abstinence for too long. But regular or constant troubles with the normal accomplishment of coitus requires medical advice and proper treatment.

It is recommended to read prescribing information carefully to learn how to take the pills. If the PE is not caused by prostatitis or the side effect of some medication, dapoxetine can cure this dysfunction. The starting average dosage is 30 mg taken from one to three hours before sex. Dapoxetine HCL should be administered on daily basis to achieve the stable and long effect. There are rigorous restrictions for dapoxetine usage:

  • one tablet in 24 hours;
  • allowed for men between 18 and 64 years old;
  • recommended to take only if the regular PE is noticed not less than six months.

Clinical research with double blinds and randomized selection with placebo control showed that 60 mg gave better results than 30 mg among men who have lifelong rapid orgasming, but men with aquired illness did not feel any difference.

Can I Take Dapoxetine and Sildenafil Together?

In some cases, men can have premature ejaculation accompanied with ED. In such cases two different substances should be used. Viagra and Priligy can work together very effectively with some precautions. Both medications can cause low blood pressure, so men with BP problems have to take this combination carefully. Only your doctor or pharmacist can give you professional advice on how to use the medications with no harm to your health.

At the same time, the two drugs have similar side effects and contraindications, systems of administration, working on different problems, and influencing the different areas or neural system. That makes these drugs highly combinable, and together they occur to be a very effective remedy for those who have problems with both erection and ejaculation. Thus, the answer for the question “can dapoxetine and sildenafil be taken together” is yes!

Is Dapoxetine Used for Depression?

DepressionDapoxetine HCL was originally developed to treat depression, but never used as an antidepressant. Being the homogeneous preparation with such pharmacologic agents as fluoxetine, sertraline, paroxetine, and other selective serotonin reuptake inhibitors, it has the different, shorter working time, and due to this aspect it does not affect depression properly.

Is It Safe?

Phase I and III trials of dapoxetine for safety showed that it has no harmful impact to men’s cardiovascular systems. No electrocardiographic abnormalities were detected in patients who took the drug.

In 2012, there were studies conducted to reveal the negative effect of dapoxetine on mood and psychiatric stability. There was no connection disclosed between the usage of this drug and anxiety and suicidal thoughts. Dapoxetine does not cause addiction or withdrawal symptoms.

How Does Dapoxetine Work?

Dapoxetine blocks the reuptake of serotonin by neurons that result in the increase of it in the synaptic cleft. High concentration of serotonin in neural system provides a better communication between brain cells. As any process in an organism, ejaculation depends on CNS, and proper messaging in nerves helps to control the length of sexual act. Another effect of dapoxetine is the temporary lowering of disturbance and frustration and mood normalization, which also positively influences sexual health, including the ejaculatory time.

How Long Does It Stay in Your System?

After oral administration, dapoxetine reaches its steady-state concentration in the blood in 1-2 hours. It is metabolized by the liver, and the time of excretion with the urine is 19 hours for 30 mg to 22 hours for 60 mg.

Dapoxetine Side Effects

A headache after dapoxetine intakeTaking dapoxetine medicines may cause some adverse effects, the most noticed of which are:

  • dizziness, especially when standing up quickly. In this case it is recommended to sit or lay down till the discomfort feeling passes;
  • fainting, sickness — also better lay down for some time not to fall and get hurt;
  • headache, nausea, diarrhea have to be treated symptomatically;
  • dry mouth, insomnia, common cold.

Usually these undesired consequences do not last for long and are mild. If they are observed for a long period of time and get severe, it is better to stop drug administration and get the instructions from doctor.

There are certain contraindications for dapoxetine usage. It is forbidden for men with cardiostimulator, ischemic disease, heart failure, liver or kidney decompensation, glaucoma, and epilepsy. It is better to ask for professional medical advice if you have any chronic diseases or take any medications.

Interaction of Dapoxetine

Interactions with drugs and alcoholAs all drugs, dapoxetine can change its action depending on how and when it was taken, and with whatever other drugs it is taken with.

Can I Use Dapoxetine with Food?

Dapoxetine can be used with and without food, and it is recommended to take it with enough water. Fat food can reduce the maximum plasma concentration of the substance, but only insignificantly.

With Alcohol

Studies did not display the effect of alcohol on dapoxetine action, though it is recommended to use alcoholic beverages in reasonable measures, as they can raise the risk of such side effects as dizziness, confusion, and fainting.

Other Drugs

Taking the serotonin transporter inhibitor with other drugs can either reduce or increase its effectiveness, or result in harmful or undesired consequences. Be careful and ask for professional consultation if you take dapoxetine with:

  • other SSRIs, monoamine oxidase inhibitors and tricyclic antidepressants;
  • antimycotics and macrolide antibiotics;
  • antiretroviral therapy;
  • nitrates and alpha-blockers;
  • tramadol and others.

Do not use dapoxetine earlier than two weeks after the last intake of any antidepressants.

Dapoxetine Comparison

This medication was the first pharmacological remedy for premature ejaculation, and it remains the best and really efficacious treatment for men with this problem. No preparation gives the same effect as quickly as the first intake.

Dapoxetine Vs Cialis (Tadalafil)

Dapoxetine and tadalafil cure different dysfunctions and cannot substitute for one another in any manner. But they can work in tandem to help men who have ED plus PE contemporary.

Viagra (Sildenafil)

As well as Cialis, Viagra is not the counterpart for Priligy and congeners but is a good remedy for erectile dysfunction. The combination of sildenafil and dapoxetine is one of the most popular treatments for both sexual disorders.

Dapoxetine Vs Paroxetine

ParoxetineParoxetine has the same mechanism of action, but it is used to treat depression. Comparing dapoxetine vs paroxetine, we should consider two sides of this matching:

  • how dapoxetine works as antidepressant;
  • and how paroxetine works as the remedy for PE.

Dapoxetine never worked for depression treatment as it does not stay in the blood for enough time. The half-life of this drug is several hours and with one time a day schedule, it is not effective in this matter.

As there is no certified drug for premature ejaculation in the USA, paroxetine has been prescribed to cure it. But the further research shows that it stays in the blood for too long, and daily administrations lead to accumulation and to such side effects as the loss of sexual desire, impotence, and others.

Fluoxetine Versus Dapoxetine

The comparison of dapoxetine vs fluoxetine will be the same as the one vs paroxetine. Fluoxetine is an antidepressant and works only for this purpose. It was attempted to be used to help with PE, but it showed adverse effects.

Dapoxetine Reviews & User’s Experience

Our online pharmacy receives dozens of comments and positive responses from customers. Their experiences using Priligy 60 mg and other dapoxetine-containing pills are all stories with happy endings. Read them and see how this innovative medication helps men all over the world who did not know how to get healthy and harmonious sexual lives before they found us.

Where to Buy Dapoxetine Online?

Online pharmacyThe CialisBit internet drugstore is the most convenient and safe ways to purchase the necessary medications. We have the richest assortment of preparations, dosages, and packages of medicaments for sexual disorders, including premature ejaculation. Our manufacturers offer the best price in India, as well as the most comfortable services.

How Can I Get Dapoxetine Without Prescription?

As in the USA and many other countries, Priligy and dapoxetine generics are not licensed, and many men ask themselves “where can I buy it without prescription”. We provide them with this possibility, along with anonymity and safety, fast shipping, and various discounts and special offers. For example, shipping is free if your order exceeds 150 dollars, and if you pay with bitcoins you get 35% discount. And the fair cost is not a sign of quality loss, as we offer reliable, safe, and efficient dapoxetine tablets, Priligy, and its alternatives.

Common Information About Viagra

Common Information About Viagra

If you’ve found yourself asking: what are Viagra’s effects, dangers, benefits, and mechanisms of action? Who makes Viagra pills and what is the history behind its phenomenal success? Does Medicare cover this medication? Where can you get pills legally? Then we have quick answers to these burning questions below.

What Is Viagra Drug?

Before you try Viagra, it’s natural that you would want to learn the details of the drug. Viagra is a popular treatment for erectile dysfunction (ED) indicated for old and young men alike.It is classified as a PDE-5 inhibitor drug.

The brand name is Viagra and it is sold under the generic name sildenafil.
These tab isn’t a permanent cure for ED, however. It is predominantly used for helping men who struggle with impotence get and keep an erection as needed.

How Does Viagra Pills Look Like?

Viagra is labeled as the «little blue pill» for good reason. Sex pills feature a four-sided design that looks like a diamond and each tab is manufactured in a light blue color.

Though it comes in different strengths, the size (length, height, and width), does not change with dosage. Instead, these prescribed amounts are imprinted on one side of each tab. The other side of the tablet is imprinted with the Pfizer logo.

Common information about Viagra

History

Viagra has a very storied past. It was first developed by Pfizer Pharmaceuticals in 1989 for hypertension and cardiovascular disease. Clinical trials were conducted to test its effectiveness for these purposes. However, the drug was proven to only work in theory and not in practice. In 1992, all development initiatives were ceased. For what it’s worth, a new opportunity arose from this crisis. About two years after the shutdown, researchers backtracked and noticed that sildenafil had an unintended and positive side effect in men that had been using the drug – this was more blood flow to the penis.

In 1996, a patent was obtained by the developers and later in 1998, the FDA officially approved Viagra for the treatment of erectile dysfunction. History at a glance:

YearMilestone
1989Viagra is developed for hypotension.
1992Productions comes to a halt after Viagra is deemed unfit for hypotension.
1994Researchers notice Viagra’s benefits for treating ED.
1996Viagra patent is obtained by Pfizer.
1998Tablets gains FDA approval.

Who Makes Viagra?

Viagra pillsOver the years, Viagra has come to be mainly associated with mega drug manufacturer Pfizer Pharmaceuticals, based in Kent, England.

According to CNN, Viagra is the sixth top seller for the company and the pill accounts for an estimated 3.5 percent of the company’s overall sales.

Pfizer continues its stronghold in the market due to a long-term patent holding. This means regional competition in the US is obsolete. In 2013, Viagra was said to generate more than $2 billion in sales for Pfizer.

Viagra Uses

Viagra is predominantly used to treat erectile dysfunction. The active ingredient sildenafil is also used to make the drug Revatio. This hybrid is administered for the treatment of pulmonary arterial hypertension in both men and women. Revatio is also considered to be a performance-enhancing drug among athletes. If you take Revatio, you shouldn’t take Viagra due to the risk of overdose. Revatio is distinguished by the fact that it is white as opposed to blue. In addition, it is prescribed in smaller dosages of 20 mg.

Dangers

As with all medicines, there is a risk of negative side effects when taking Viagra. The most common adverse effects are nasal blockages, dizziness, headaches, upset stomach, and blurred vision.

Chest pain

Some of the most serious side effects while taking tabs include:

  • vision loss;
  • chest pain;
  • hearing loss;
  • an erection that lasts more than four hours;
  • labored breathing;
  • rashes.

If you experience any of these symptoms, seek medical help right away. Another major danger when taking pill is its interactions with nitrates. If you take another medicine that contains nitrates, do not use Viagra. This combination can cause life-threatening drops in blood pressure. Moreover, due to the risks of anaphylaxis shock, you should discuss with your doctor if you have experienced any allergic incidences in the past.

There are a few more warnings published by the FDA and these include telling your doctor if you take alpha-blockers for high blood pressure. Viagra users should also follow the printed directions exactly as prescribed.

A Little About Benefits

Viagra has been proved to be an effective way to treat erectile dysfunction in clinical studies.

Long sexual intercourseIn fact, it is one of the most popular drugs on the market for impotence. Some of Viagra’s top benefits include:

  • it lasts for up to 4 hours;
  • erections can be achieved within 30-60 minutes of use;
  • it’s easy to take orally; and no injections or invasive treatments are needed;
  • it is well-tolerated by the majority of users;
  • Viagra is considered to be the most effective PDE5 for ED;
  • it has minimal side effects.

The benefits of Viagra extend beyond the bedroom. Men who experience a recharged sex following impotence, for example, get a fresh dose of confidence to tackle other areas of life. For men who experience erectile dysfunction on a regular basis, the little blue pill is ultimately a game changer for maintaining an active sex life.

What Types Has Viagra?

Since the inception of Viagra nearly 20 years ago, different hybrids have been manufactured to satisfy the needs of certain demographics. The newest generations of Viagra include:

Extra Super ViagraFor ED with premature ejaculation.
Female ViagraFor the treatment of female sexual arousal disorders, it works by modifying chemical imbalances in the brain.
Red ViagraConsidered to be stronger than standard Viagra.
Viagra GoldA more potent dose of original Viagra pills.
Viagra JellyA softer more edible form of Viagra.
Viagra PlusOriginal Viagra enriched with herbs for a harder erection.
Viagra ProfessionalPrescribed for ultimate sexual performances.
Viagra SoftFormulated to enter the bloodstream faster than the original version of Viagra.
Viagra Soft FlavoredFor men with very discerning taste, these pills are flavored with pineapple, orange, strawberry, and other fruits.
Viagra Super ActiveThe 4th generation underwent several improvements to speed up the time it takes for an erection to kick in.

Mechanism of Action

One of the most common misconceptions of Viagra is that it promotes sexual arousal. The drug only works, however, if a man is turned on sexually.

Erection

To learn how pill works, you have to look into how an erection is achieved. The inner workings of an erection involve:

  • men have to be sexually stimulated;
  • nerves in the penis release nitric oxide (NO);
  • nitric oxide fuels enzymes that generate messenger cyclic guanosine monophosphate (cGMP) facilitates better blood flow to the penis by relaxing muscle cells.

How does Viagra fit into the grand scheme of things? It helps men achieve and keep an erection by sustaining cGMP levels. For the best results, men should read the full details of how it’s used and take Viagra at least an hour before sexual activity.

Medicare and Viagra

Erectile dysfunction affects men of all ages, however, it’s more prevalent in older men. Men who qualify for Medicare most often fall into the same group of users who need Viagra the most. For men over the age of 65 on fixed low incomes, the cost of Viagra is usually out of reach because Medicare covers 0% of the cost of this drug.

MedicareNeither Medicare Part A nor B covers Viagra prescriptions, mainly because the drug is indicated for recreational use only. There are a few exceptions for when Medicare covers Viagra, which are for medical reasons only.

As an alternative, seniors may sign up for either the Medicare Advantage Prescription Drug plan or a separate Medicare Part D prescription drug plan.

These are organized by private insurers and it allows enrollees to get discounts on certain drugs – not including Viagra. Many seniors use the monthly savings applied to other drugs to pay for Viagra. Some experts believe that should Viagra go off patent in the US, the high prices will plummet significantly as is the case with UK-based Levitra.

Where to Buy Viagra Over the Counter?

According to the FDA, OTC drugs must be effective and safe to use – even without consulting with a doctor before using.

As of today, you still need a prescription to get Viagra over the counter no matter where you go. These pills has long vied with overseas manufacturers where no patents or trademarks restrict competition. With fewer regulations in foreign markets and global trading open to consumers worldwide, it’s now easier than ever to get Viagra without a prescription online.

Online pharmacies regularly run quality control tests to ensure all the drugs sold on the platform are made with ingredients that meet high-quality standards. Since there are no red tapes, traditional overheads, or trademarks to factor into our pricing strategies, we are able to sell popular generics at rock bottom prices.

Viagra is sold in a variety of dosages and packages. The most common are 25 mg, 50 mg, and 100 mg. On online pharmacies such as CialisBit, you can typically order smaller quantities of 10 packets or even bulk orders. Wholesale Viagra orders feature a lower price per unit regardless of the prescription amount being ordered. More information can be accessed by browsing our website.

Is It Legal?

FDA approvedIt has already been established that Viagra is approved by the FDA and it has enjoyed a long track record of success. Due to lenient international trade laws along with ambiguity clauses for operating businesses online, it can be determined that ordering Viagra from an online pharmacy without a prescription is completely legal.

In a paper by the National Bureau of Economic Research titled «The Role of Certification Agencies in Online Drug Markets», the research firm articulated that millions of Americans are turning to international-based online pharmacies to access low-cost drugs. The paper also confirms it is safe to do so. The underlying factors behind this growing trend are money savings and convenience. The average savings listed by the study when consumers purchase drugs like Viagra from online pharmacies is roughly 52.5 percent. An estimated 5 million Americans have made the switch and this number is expected to grow.

Viagra Dosages

Viagra Dosages

Learn all about recommended, normal, maximum safe and minimum effective dosages of Viagra. If you are interested does dose depend on age or weight and you do not know what Viagra dosage to choose, then we recommend reading this article. You will see the answers to all the questions.

What Doses Does Viagra Come In?

Choosing the right Viagra dosage can be much more complicated than it first seems. Making the best choice means considering a wide range of factors including your weight, age, and medical history. But beyond the basics, you also need to understand all of the available information about the drug itself: what is the minimum effective dose per day, and how different levels of strength will affect you.

One of the major questions first-time users ask is what doses does Viagra come in? If you were wondering this yourself, you will be pleased to learn that there are many available options to choose from that can affect duration and frequency. Take a look at the chart below for a comparison of some of the most popular generic dose.

DosageMeaning
10 mgA low dose, made for daily use.
25 mgA slightly higher daily dose.
50 mgNormal tablets that provide a medium effect.
100 mgThe next step up, after an initial trial.
150 mgA high dosage option for a powerful effect.
200 mgA maximum dose for Viagra experts.

Viagra 25 Mg Tablets

25 mg tablets are a versatile dosage that can be used every 24 hours for a treatment to erectile dysfunction, as well as a one-time solution to a night of frustration. Many men prefer daily doses, finding the regular rhythms more convenient and easier to predict.

Viagra dosages

Viagra 50 Mg Pills

Viagra 50 mg is the proper dose for those trying the drug for the first time. Strong enough to relieve ED symptoms quickly, while also safe enough to avoid overdose effects, it is a happy medium that works for most. And after you get used to the effects, doubling the dosage can be a smart next step.

Viagra 100 Mg Tabs

50 mg vs 100 mg has been a longtime debate for men trying to decide which Viagra levels are best for them. 100 mg is recommended for men who have tried the 50 mg tablets and could use a bit of extra power without fear of increased side effects. Many men think that generics are not as strong as brand names, and use a higher dosage for best results.

Viagra pills

Buying 100 mg tablets is one of the most economic ways of ordering. In our online pharmacy, you can buy this bestseller with a 35% discount using Bitcoins.

Other Viagra Dosages

Aside from the options listed above, there are varieties as well. Some of these, like Viagra for women and herbal varieties, are listed below. There are also different dosage levels to help men transition between different levels. In some cases, 120 mg Viagra is the correct option for men looking for a small boost beyond the 100 mg option. Can you take more than 100 mg? Yes. In fact, there are 120, 150, 200 mg doses and beyond, for those wanting to find the limits of their own sexual prowess. Get all the info about higher Viagra doses on cialisbit.com.

What If My Current Dosage Didn’t Work?

When discovering which dosage works best for you, a little bit of trial and error is inevitable. Making sure you don’t take too much is important, but if your current dosage isn’t getting the response you are looking for, trying out stronger options is the way to go.  The conversion process to higher doses should be taken step by step, to avoid negative side effects.

Overdose

To avoid the negative side effects associated with Viagra overdose, make sure to follow the instructions included with your medication. Before taking your first pill, check the available guide to answer questions like «how long does it last», and «how strong is my favorite dosage» and «should I take my medication with food?» The answers can be different for each type of medication, which is why getting the official answers is important.

Dosage of Viagra Type

Making sure you get the ideal dosage is all about gaining insight into the different types of Viagra available. Some of the most popular varieties include Female Viagra, Viagra Professional, Viagra Soft, and Viagra Extra Strength, and each of these different options comes with varying recommended doses. See the descriptions for three of these options below, to understand better how they can affect your system.

Herbal

Types of Viagra

Herbal Viagra is a name commonly given to various herbal supplements that promise to increase the strength and duration of male erections, or to relieve the effects of ED. On the one hand, some of these solutions can be new and innovative treatments for problematic diseases. However, it is important to understand that the effects of these supplements can vary wildly, and there is no reliable way to gauge dosage. In no case should not engage in self-medication. Contact your doctor and he will tell you which option suits you.

Female

One thing many men and women aren’t aware of is the growing popularity of female Viagra across the world. It works through a different mechanism of action than the male variety does; however, initial studies have shown that it boosts sexual stimulation for women. You can find out more about this new drug on cialisbit.com and order your first dose today.

Soft

Viagra soft is specifically designed for men who prefer quicker effects and simpler dosing than the original formulation. This medication comes in the form of a lozenge that dissolves in the mouth and delivers the same active ingredient directly to the bloodstream. In some cases, a lower dosage is required for new users.

What Dosage Should I Choose?

If you are still asking what dose is right for me, then breaking the options down by the factors that matter to you is the next step. See the table below to help you think through the process:

CostIn some cases, higher doses will fetch a higher price.
Side effectsIf the side effects are too much to handle, cutting down your dose is the safe choice.
AgeLower doses are ideal for seniors, while younger men prefer stronger treatment.
WeightBuying by body weight is a smart idea, as heavier individuals will use more of the same drug to get similar effects.

Where to Buy Cheap Viagra Without Prescription?

Cialisbit.com offers all of the available doses to bring the max effectiveness and reliable results to men all over the world. Whether you are using the pills for recreational purposes, mild ED, or starting on your very first dose, finding exactly what you are looking for will be a walk in the park. For more information, take a look at a few typical reviews from customers just like you on the effects of Viagra, Cialis and Levitra.

Female Cialis Benefits

Female Cialis Benefits

There is plenty of misinformation about female Cialis spread across the internet, making it hard for women to really know what happens when taking it, or what kind of side effects to expect.

Since it has proven to be such an effective treatment for men, wondering what would do to a woman is only natural. For women, the first step toward a safe experience with this medication is to arm yourself with the knowledge you need to start your own order.

Can women take Cialis for men? To find your in-depth answer, take a look below and find out what kind of effects to expect, along with information on dosage and use. With plentiful data on first-hand experiences with the drug, getting a trustworthy perspective is not as difficult as it may seem.

What Is Cialis for Women?

Cialis for women is a rebranded version of the drug designed to affect women specifically. If the customer reviews are any indication, the drug does work as intended and is available in generic varieties through online pharmacy. Cialis for women represents one of the first steps toward safe and effective sex drugs created with women in mind. While there are still many questions that need answering, many are excited to experience the results.

Female Cialis Benefits

How Does Female Cialis Work?

Female Cialis has proven to have a consistent and noticeable effect on women, according to recent studies. While some women did not report a substantive change in their sex drive, many showed increased arousal and sexual stimulation.

Researchers believe that Female Cialis works similarly to the way it stimulates erections in men, by increasing blood flow across the body. While it may not have as powerful an effect on the female body, the increased blood flow is meant to increase sensitivity. This, in turn, helps stimulate orgasms more quickly and for longer periods of time.

Dosages

Cialis 20 mgFemale Cialis comes in all of the varieties that the traditional drug can be found in, including lower doses designed for daily use. As always, choosing the right dosage for your needs should be a process of starting low and working your way up. A 5 mg or 10 mg dose is ideal for first-time users, reserving 20 mg for more experienced patients. Take a look at the chart below for a list of different dosage options:

  • 5 mg – low dosage, for daily use;
  • 10 mg – medium dosage, to be taken before sex;
  • 20 mg – high dosage, to be taken before sex.

Side Effects of Female Cialis

As Female Cialis is only a recently released drug, not all of the side effects have been fully studied. However, initial indications show relatively minor and infrequent reactions, meaning Female Cialis seems to be as safe and predictable as the original version of the drug. Take a look at some of the more common side effects listed below. If any of the following occur for more than 24 hours, see a doctor immediately:

  • flushing redness;
  • upset stomach;
  • sneezing;
  • sore throat;
  • back pain;
  • low blood pressure;
  • blurred vision.

How Should I Take Cialis for Women?

Female CialisSince Cialis for Women uses the same formulation as the male variety and can be taken in much the same way. One of the greatest benefits to the drug is that it is designed to be fit into an active lifestyle, which means that it can be taken with or without food, and begins working in as little as 30 minutes.

If you are taking the drug for the first time, read the package insert that comes with the medication carefully. Ingest the drug orally 30 to 60 minutes before sex, and do not combine with alcohol. For a full list of drug interactions, check your insert. After you gain some initial experience with the drug, you will become more aware of the specific way it interacts with your system and plan accordingly.

Is It Safe?

Initial studies show that Female Cialis is just as safe as its male counterpart, and perhaps even more so, as some of the effects are less pronounced in women. Additionally, customer reviews and testimonials indicate a positive response among the vast majority of first-time users. Until official tests are complete, women can rest their confidence in the experiences of those who have used the drug thus far.

In case of unusually strong side effects, it is best to call your doctor immediately and receive attention. As the side effects of Cialis have been thoroughly studied among men, such incidents are rare.

What If Woman Takes Cialis for Men?

The difference between female and male Cialis ultimately comes down to branding, and if a woman takes Cialis for men, they can expect similar results. While research for sex drugs designed specifically for the female body is well underway, it seems that buyers will need to continue their wait. Luckily, traditional Cialis has already proven its effects across a growing female user base. As the drug continues to gain popularity among both genders, we can expect further advancements that will benefit us all.

Benefits of Female Cialis

OrgasmFemale Cialis comes with a number of unique benefits that women are able to enjoy for themselves. If you have yet to try the drug for yourself and are curious about what sort of effects to expect, take a look at the list below:

  • increased blood flow across the entire body;
  • heightened sensitivity and increased response to genital stimulation;
  • longer, more intense orgasms.

Getting Started on your own Dosage

Female Cialis is still relatively rare on the online market, and so finding a dosage may not be the most straightforward process. However, as long as you know where to look, you should be able to find your own dosage at a price that can fit any budget. Just be sure to choose a reputable seller that can answer all of your questions about emerging varieties of Cialis.

Cialisbit.com offers the generic variety of Cialis for women at affordable prices. Shipped directly to your door in discreet, unmarked packaging, women across the world can take advantage with minimal hassle. To place your order today, simply visit cialisbit.com, search for Cialis for women, choose your dosage, input shipping information and await delivery.

Viagra Interaction: with Alcohol, Food and Other Medications

Viagra Interaction: with Alcohol, Food and Other Medications

Learn more about how Viagra interacts: with alcohol drinks, food, other medications and drugs. What you should avoid while taking Viagra? Safe ways to use sildenafil pills.

Countless numbers of men suffer from erectile dysfunction at some point in their lives. In fact, studies suggest that approximately half of all men experience ED. It’s just as common as heartburn and indigestion.
Despite this, a certain stigma remains attached to the condition, and many men are reluctant to discuss erectile problems with their doctor.

However, modern medicine provides us with a number of different treatments to combat ED. The most popular is a compound called Sildenafil citrate, which is more commonly known as Viagra.

Who Can Use Viagra Pills?

Viagra can be used by men of all ages in order to alleviate the physical symptoms of erectile dysfunction. An oral dose of Viagra functions by relaxing muscle cell walls, thus allowing blood to flow more freely to the penis to achieve an erection.

Viagra can also be used to treat pulmonary hypertension. In fact, the drug was first developed for this purpose. During trials, many men noticed that one of the main side effects was the ability to achieve and maintain an erection. The drug has been marketed as such ever since, although it does have a number of different ‘off-label’ properties, too.
Viagra Interaction: with Alcohol, Food and Other Medications

Interaction of Viagra

With Alcohol Drinks

Health professionals advise that alcohol should, in general, be avoided while using Viagra and similar compounds. Although it is possible to have one or two drinks, it is best to err on the side of caution. The side effects of alcohol are similar to those of Viagra in many respects, and combining the two can increase the risk of experiencing unpleasant headaches, flushes, fainting and more.

May I Drink Wine or Beer While Taking Viagra?

Wine and BeerDoctors recommend that no more than one or two units of alcohol are consumed while taking Viagra, which means no more than a glass or two of wine or beer. It’s understandable that alcoholic drinks can be part and parcel of the dating process, but it’s wise not to go too overboard – particularly if you are taking Viagra for the first time.

The answer to the question “can you take Viagra with alcohol” is quite simply “everything in moderation”. If you can avoid it you should – try not to mix the two.

With Food

You may be wondering should you take Viagra with food – the answer is to avoid taking it on a full stomach if possible. Fatty foods and food rich in protein will mean that Viagra takes longer to work. Viagra us absorbed via the stomach, and with a full stomach, the drug has to “queue” while your body digests the meal, which will delay the time and potentially the effectiveness of a Viagra dose.

A qualified medical professional will be able to provide more concise directions regarding food and Viagra tailored to your requirements.

Should I Take It on Full or Empty Stomach?

You should aim to take Viagra on an empty stomach where feasible. The drug will function more effectively in these circumstances and will last for upwards of 2 hours.

Avoid Greasy Foods

Greasy FoodsIf you’re wondering should you take Viagra with food, the good news is that you don’t have to starve – however, you should aim not to eat with greasy, oily meats and seafood. Although these foods won’t interfere with the way the drug works, they will slow down the process and block the drug from getting to work straight away, so it’s best to avoid them.

Of course, a date night often involves a meal – if this is the case, a plant-based dinner such as a salad is the best food to eat with Viagra. Viagra could be crushed in food if you aren’t fond of taking pills, but for maximum effectiveness, the tablet should be taken a short time after eating, between an hour and 30 minutes prior to engaging in intercourse.

Can I Take Viagra with Grapefruit or Pomegranate?

Although a variety of different fruits can be eaten while taking a dose of Viagra, grapefruit, grapefruit juice and pomegranate should be avoided directly before or after taking the drug, at all costs. Certain enzymes present in grapefruit stop Viagra from breaking down in the body, which results in a much larger uptake of the drug. Medical professionals insist that you don’t eat any products containing grapefruit before taking Viagra, as you may put yourself at risk of experiencing the following symptoms:

  • flushing;
  • headaches;
  • fainting;
  • low blood pressure.

Is it better to leave a day or two between taking Viagra and eating grapefruit? Undoubtedly so. How long after you can take Viagra will depend on individual physiology, and health professionals recommend that you don’t eat grapefruit for at least 24 hours before or after Viagra, although how long to wait is solely at your discretion.

You may be wondering “can you take Viagra with other citrus fruits”, and the answer is yes. The enzyme which causes interactions with the drug is exclusive to grapefruit.

Warning: Nitrates in Food

Nitrates in FoodAlthough Viagra can be taken with or without food, it’s important to consider what you are eating. There are nitrates in food products like cured meats, bacon and sausages which can cause serious side effects. If you’re wondering “are you supposed to avoid salami and pepperoni when taking Viagra?” the answer, unfortunately, is yes.

Viagra and Other Medications Intake

There are restrictions on certain medicines with Viagra. You should avoid medication intake of the following drugs as the side effects can be potentially dangerous:

MedicationInteraction
NitroglycerinCauses blood pressure to fall rapidly
BoceprevirIncreased blood levels of Sildenafil
OmeprazoleIncreased blood levels of Sildenafil
ClarithromycinPotentially increased blood levels of Cialis

These are just a handful of medicines which should be avoided. For a more comprehensive list, you should consult your doctor.

L-Arginine

L-ArginineL-arginine is a vital amino acid which helps to create proteins. In the body, it becomes nitric oxide (NO) when present in the body. NO can help blood vessels relax, therefore allowing blood to circulate more freely through the arteries. This is important in terms of both achieving and maintaining an erection. A healthy diet ensures that the body receives enough L-arginine. Some consider L-arginine supplements as an alternative way to combat ED – although, versus Viagra, the results are negligible.

Antibiotics

You may be wondering “are you supposed to take Viagra if you are on antibiotics”?

Certain antibiotics – such as Amoxycillin – can affect levels of Viagra in the blood. Caution is advised when taking these medicines. You may find is it better to take a lower Viagra dose when on antibiotics, or to abstain from taking it completely.

Warfarin

Blood pressure medications like Warfarin should not be mixed with Viagra, as this can lead to a potentially fatal drop in blood pressure, which it turns can cause arrhythmia or cardiac arrest.

Can I Take Viagra with Drugs?

DrugsRecreational drug use should be avoided when using Viagra. Certain drugs, like poppers (amyl nitrate), can be potentially fatal when combined with erectile dysfunction medicines. Other drugs can cause complications like a fast heart rate. It is, therefore, imperative that recreational drug use is avoided when taking Viagra.

For further information on what to avoid when using erectile dysfunction medication, you should always consult a qualified medical professional.

Does Expired Cialis Work?

Does Expired Cialis Work?

This article is about Cialis shelf life. Want to know what is it? How long lasts Cialis before expiration? Is it safe to take expired Cialis pills?

Those who have been taking Erectile Dysfunction medication tablets can attest to their effectiveness. But what most people do not know is how long does Cialis last before it expires. The main reason for the gap in understanding has to do with the fact that the exact expiration date is difficult to pin down, because of the nature of the drug itself. However, by following a few simple rules, you can ensure that you always get the most of your favorite medication.

If you find yourself staring at your old bottle of Cialis sitting in your medicine cabinet and wondering “does expired Cialis still work?” then looking below for answers is your solution. Read on to understand everything you need to know about when you can take the drug and stay safe, and how ingesting expired Cialis could affect your system.

What Is Cialis Shelf Life?

Some experts say that Cialis’ shelf life is as little as one year, while others say it is safe to take up to two years. However, in the case of Erectile Dysfunction medications, leaning toward the conservative side is always a good bet in order to stay safe. And so, a good rule of thumb for Cialis usage is to take it within one year for maximum potency.

And so, the short answer to the “what is the shelf life” question is one year. However, there are a large number of factors that can affect this number. For more information on these, and how they can affect your Cialis experience, read below.

Does Expired Cialis Work?

Is Expired Cialis Still Safe?

Many men wonder “can you take expired Cialis” and while the answer is a tentative yes, it is important to understand the possible effects that may come with ingesting it beyond its shelf life. Expired Cialis begins to chemically decay beyond this point, leaving the user with less effective pills. The medication itself is not dangerous or toxic, however, it is impossible to know whether you are getting a full strength pill or one that will deliver decreased results.

How Long Does Cialis Last Before It Expires?

Cialis lasts a full year before it expires, however, this number can change based on a number of different factors. For more information, take a look at a few of these variables listed below:

  • manufacturer – different manufacturers process their medications in different ways, and each can lead to different expiration dates. This is why it is always good to stick with a single supplier for consistent results;
  • pharmacy – any given pharmacy can store and handle their drugs differently from the next, and all of these factors will change the way your Cialis ages;
  • storage – after the pills are safely in your possession, the way you store them will affect their shelf life. For best results, store them in a cool, dry place.

Does It Work the Same After Expiration Date?

Cialis tabletsDoes Cialis expire? Yes. Does it work the same past its expiration date? Definitely not. As the medication decays over time its effects will weaken, leading to a less effective drug. While some may simply decide to simply take additional pills to compensate, this is not recommended, as there is no way to tell how much your medication has degraded over time. Taking more than your Cialis recommended dosage can lead to unexpected or even dangerous results.

If your bottle of Cialis is past its expiration date, your best bet is to simply purchase a new shipment as soon as possible. While it might run you a bit extra, it is better than suffering the results of overdose. In the future, making sure you order the right amount will ensure that you make it through your supply before it expires.

Can You Take Expired Cialis Pills?

There is no way to tell if your Cialis is expired just by looking at it, which means you need to rely on your calendar, and on the experience of professionals. When in doubt, it is always better to simply place a new order, rather than putting yourself in potential danger.

However, if your heart is set on trying expired Cialis pills, then one tip would be to check with your supplier first. They will have the best insight into how long your particular bottle is good for and offer the most detailed and accurate advice for taking it. If you try a pill and the results are the same as always, it means you are in the clear for a few more weeks. Though if the results seem lessened, then it is probably no longer good.

Ordering Strategically

CialisThe best defense against taking expired Cialis is ordering strategically and ensuring that you have the right amount of pills for your needs. Many online pharmacies that deliver to the US, like cialisbit.com, offer incentives to order in bulk, such as free shipping on orders above $150. However, taking advantage of this means understanding your own usage habits.

If you are new to Cialis, then start by ordering small and work your way up. Keep track of your usage for the first month, and count the number of pills you take during this period. Then multiply this number by twelve and you have the maximum number of tablets you can order for a one year period. As long as you stay relatively consistent in your usage, you can continue buying one year at a time, or break your ordering cycle into six-month increments if you prefer.

Calculating your Bulk Order

Different online pharmacies will offer a range of different prices, and getting a grip on your favorite shop’s rates is important. Let’s take cialisbit.com as an example of a low-priced pharmacy that offers incentives for buying in bulk. See some of their rates in the table below:

  • 10 pills $2.99 per pill;
  • 20 pills $2.49 per pill;
  • 30 pills $2.29 per pill;
  • 50 pills $1.59 per pill;
  • 100 pills $0.89 per pill;
  • 200 pills $0.83 per pill;
  • 300 pills $0.79 per pill.

Another way to save

ManAnother option for men starting out on their first order of Cialis is to try a free sample. Many forward-thinking online pharmacies today offer samples of their most in demand drugs to first-time customers.

The idea is that they are so proud of their product that they are eager to let newbies experience the quality first hand. It is good news for first-timers looking to save some cash and try something totally new.

To get started, simply visit cialisbit.com and click their Free Samples tab.

They offer samples in all of the most popular ED drugs, and you will be able to take your pick from any of them. After paying a small shipping charge, you will be able to get all the information you need to place a full order.

How to Get Free Erectile Dysfunction Drugs

How to Get Free Erectile Dysfunction Drugs

Want to know where and how to get free trial erectile dysfuncion drugs? Read this article to learn all ways to get free ED pills.

Men have suffered from erectile dysfunction for decades, losing their ability to achieve a consistent erection during sex and often sapping the passion that had once made their relationships so strong. With the majority of men experiencing the condition at some point in their lives, it has become one of the most common and serious conditions in existence. However, in the mid-nineties, Viagra was brought to the market for the first time by the Pfizer Corporation, promising strong and consistent erections for all men, as well as healthier and more satisfying love lives. Now that most men across the world have heard of or even tried Viagra for themselves, it has become one of the most popular drugs as well. Shortly after, Cialis and Levitra joined the fray to bring their own unique results as strong alternatives. Today, the only downside to all of this is that these drugs fetch increasingly higher prices. As a result, many men are not able to try it for themselves and earn all of the life changing benefits. If this describes you, read below for a number of different solutions that can put one of the most popular and effective drugs in your pocket.

Viagra is a drug made to treat erectile dysfunction for men. As one of the first and certainly most popular options within this category, it has earned a steady reputation for itself over the years.

This is the drug’s main benefit, a reputation that allows users to trust that they are getting consistent results each and every time they take it. However, when stacked up against other ED meds like Cialis or Levitra, Viagra has a few other benefits to take note of. For one thing, it is proven to be stronger, offering longer lasting erections for those who take it. It is also one of the most versatile, as it allows doses from 5 mg to 100 mg for different uses and strengths. Finally, it can be taken with food, making it easy to incorporate into any healthy lifestyle.

How to Get Free Erectile Dysfunction Drugs

The Challenges

The key challenge with Viagra and other ED meds are their cost. When buying real Viagra in the USA, pills are often ordered directly through the Pfizer corporation, who ask for up to $50 per pill in certain cases. For many budgets, this price is simply impossible without a good insurance plan, leaving millions across the world without any way to get the medication they need for happy and healthy relationships. Another major hurdle for those trying to get their hands on the pill is the prescription requirement. It is common for men experiencing ED to be shy about sharing their condition with their doctor or even stopping by the pharmacy to pick up their prescription. In each case, many men simply do without.

Where to Get Free Viagra Pills?

Free Viagra SamplesThe good news is that there are plenty of ways to get free Viagra pills by mail that won’t have you jumping from doctor to doctor. Doing so offers the double bonus of bringing quality medication at just a fraction of the price, while also delivering it directly to your door. Mail order Viagra allows users to skip embarrassing doctor visits and hassling trips to the local pharmacy. Orders are often shipped in unmarked packaging to allow for maximum privacy. If you are wondering how to get your own free, or reduced cost Viagra, try out some of these options, or read below for more detailed information.

  • Viagra samples with 3, 6, or 100 free pills;
  • coupons;
  • pharmacy voucher;
  • sample pack deals;
  • generic medications.

Free Samples

It may sound like a bit of a surprise, but there are actually a number of online pharmacies who are eager to give away free samples to new and old customers alike. The idea is that once you try the quality medications they have to offer, you will be so impressed that you will keep on coming back for more. Free ED trial samples are one of the quickest ways to tell if a pharmacy is confident about their product, and should be a good indicator for a trustworthy source. The way it works is you find a supplier who offers free samples of Viagra or your favorite ED medication of choice, and simply place your order. While many of these websites will charge a nominal shipping fee, this price will still save heaps of money over the competition, making it a risk-free way to try something new and beneficial.

Coupon and Voucher offers

Even if you can’t find totally free samples of the medications you are looking for, there are always plenty of different coupons floating around for those who need their ED med fix. This could be a good option for first-timers but is definitely well suited to those who already love Viagra and want to put in a larger order to keep them going for longer. Different coupon and voucher offers can cut back on shipping, cut costs in half, or let you buy more for less.

Cialis Free Offer

Free Cialis Trial PackOne option to try right off the bat could be Cialis free pills. There are many websites who offer 30-day samples of this effective drug without prescription, delivered to your door overnight. Whether you go with generic or name brand Cialis, it can be a perfect solution for those who want to try something a bit different. And now, Cialis even offers professional formulations, which allow users easier integration of the drug into their everyday lives.

Levitra Samples without Prescription

Levitra is another excellent alternative ED medication if you are looking for slightly different results. The newest medication out of the three, it has begun turning heads by offering reliable results that live up to users’ expectations. At the end of the day, the option of three different major name brand ED drugs means getting to choose the one that works best for your system. Even if you don’t get the desired results from your first choice, most will be able to find an ideal solution in one of the other two.

Generic Drugs

If you are shopping for ED meds online without a prescription, chances are you are looking at a selection of generic drugs. As the name suggests, generic medicines are those sold outside of major brand names like Viagra or Cialis and are instead marketed under the name of their chemical compound. Aside from this, there are two major factors that distinguish generic drugs from one another. The first is the cost. Generic drugs can often be obtained for under $2 per pill and in some cases as low as $1 per pill! And while the price hits rock bottom, the quality remains the same. Generic drugs are so popular online because they offer the exact same results as the name brand options. Trying them out for yourself should be at the top of any to-do list. Take a look at the table below for a guide to common ED medications and their generic names.

  • Viagra – Sildenafil;
  • Citrate Cialis – Tadalafil;
  • Levitra – Vardenafil;
  • Staxyn – Vardenafil;
  • Stendra – Avanafil.

Other Ways to Try on Erectile Dysfunction Drugs

Aside from the options listed above, the internet is full of different ways to bring quality medications to the people who need them most. Do a little research and browse through your favorite online pharmacists to see what new and exciting deals they are offering this week. After you get a lay of the land, you will become an expert at finding the newest and best deals available. Also you need to try erectile dysfunction Combo Pack – to learn what medicines work best of all.

Choosing the Right Pharmacy

Viagra, Cialis and Levitra Free PillsNo matter how you plan on getting your free or discounted Viagra meds, understanding how to choose a trustworthy supplier is everything. The first and most obvious factor is price. After you get your free samples, and cash in your coupons, will you be able to keep returning for low prices? Make sure to check how they treat their long term customers as well as their new converts. The second quick and easy way to gauge a new supplier is to look at what past customers have to say. A quality CialisBitcoins online pharmacy will be ready and able to share past customer Viagra and Cialis testimonials that can give greater insight into how good of a company they really are. Look for noteworthy praise covering everything from customer service, to shipping times, to quality of medication. In time, you might be one of the many singing the praises of your new pharmacy!

Taking Action Today

There is no better time to start than now for getting affordable ED medications. Become one of the many to bypass the doctor’s office visits, long pharmacy lines, and over-inflated prices to reach a lifetime of sexual satisfaction. Freebies are always a great way to start since they pose no financial risk whatsoever, allowing you to enjoy the results without stress or fear. Still wondering “where can I get my free ED drugs” or have any further questions or concerns about how to get started before buying? Get in touch with a trusted online pharmacy today and witness their customer service skills first hand!